The Gut Microbiome in Pancreatogenic Diabetes Differs from That of Type 1 and Type 2 Diabetes

Overview

Journal Sci Rep

Specialty Science

Date 2021 May 27

PMID 34040023

Citations 11

Authors

Rupjyoti Talukdar

Priyanka Sarkar

Aparna Jakkampudi

Subhaleena Sarkar

Mohsin Aslam

Manasa Jandhyala

G Deepika

Misbah Unnisa

D Nageshwar Reddy

Affiliations

Soon will be listed here.

Abstract

We hypothesized that the gut microbiome in patients with diabetes secondary to chronic pancreatitis (Type 3c) is different from those with Type 1 and Type 2 diabetes. This was a cross-sectional preliminary study that included 8 patients with Type 1, 10 with Type 2, 17 with Type 3c diabetes and 9 healthy controls. Demographic, clinical, biochemical, imaging and treatment data were recorded and sequencing of the V3-V4 region of the bacterial 16SrRNA was done on fecal samples. Bioinformatics and statistical analyses was performed to evaluate the differences in the diversity indices, distance matrices, relative abundances and uniqueness of organisms between the types of diabetes. There was significant difference in the species richness. Beta diversity was significantly different between patients with Type 3c diabetes and the other groups. 31 genera were common to all the three types of diabetes. There was significant differences in the species level taxa between Type 3c diabetes and the other groups. The unique bacterial species signature in Type 3c diabetes compared to Type 1 and Type 2 diabetes included Nesterenkonia sp. AN1, Clostridium magnum, Acinetobacter lwoffii, Clostridium septicum, Porphyromonas somerae, Terrabacter tumescens, and Synechococus sp.

Citing Articles

A systematic review on gut microbiota in type 2 diabetes mellitus.

Chong S, Lin M, Chong D, Jensen S, Lau N Front Endocrinol (Lausanne). 2025; 15:1486793.

PMID: 39897957 PMC: 11782031. DOI: 10.3389/fendo.2024.1486793.

Establishment and perturbation of human gut microbiome: common trends and variations between Indian and global populations.

Chandel N, Maile A, Shrivastava S, Verma A, Thakur V Gut Microbiome (Camb). 2025; 5():e8.

PMID: 39776539 PMC: 11704572. DOI: 10.1017/gmb.2024.6.

Genetic Evidence for the Causal Relationship Between Gut Microbiota and Diabetic Kidney Disease: A Bidirectional, Two-Sample Mendelian Randomisation Study.

Zhang Y, Zhao L, Jia Y, Zhang X, Han Y, Lu P J Diabetes Res. 2024; 2024:4545595.

PMID: 39479291 PMC: 11524706. DOI: 10.1155/2024/4545595.

Genome-scale community modelling elucidates the metabolic interaction in Indian type-2 diabetic gut microbiota.

Beura S, Kundu P, Das A, Ghosh A Sci Rep. 2024; 14(1):17259.

PMID: 39060274 PMC: 11282233. DOI: 10.1038/s41598-024-63718-0.

Evaluation of the Crosstalk Between the Host Mycobiome and Bacteriome in Patients with Chronic Pancreatitis.

Sarkar P, Chintaluri S, Sarkar S, Unnisa M, Jakkampudi A, Mulukutla A Indian J Microbiol. 2024; 64(2):603-617.

PMID: 39011022 PMC: 11246408. DOI: 10.1007/s12088-024-01207-8.

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