Inorganic Agents for Enhanced Angiogenesis of Orthopedic Biomaterials

Overview

Journal Adv Healthc Mater

Specialties Biomedical Engineering
Biotechnology

Date 2021 May 26

PMID 34036754

Citations 10

Authors

Monika Salandova

Ingmar A J van Hengel

Iulian Apachitei

Amir A Zadpoor

Bram C J van der Eerden

Lidy E Fratila-Apachitei

Affiliations

Soon will be listed here.

Abstract

Aseptic loosening of a permanent prosthesis remains one of the most common reasons for bone implant failure. To improve the fixation between implant and bone tissue as well as enhance blood vessel formation, bioactive agents are incorporated into the surface of the biomaterial. This study reviews and compares five bioactive elements (copper, magnesium, silicon, strontium, and zinc) with respect to their effect on the angiogenic behavior of endothelial cells (ECs) when incorporated on the surface of biomaterials. Moreover, it provides an overview of the state-of-the-art methodologies used for the in vitro assessment of the angiogenic properties of these elements. Two databases are searched using keywords containing ECs and copper, magnesium, silicon, strontium, and zinc. After applying the defined inclusion and exclusion criteria, 59 articles are retained for the final assessment. An overview of the angiogenic properties of five bioactive elements and the methods used for assessment of their in vitro angiogenic potential is presented. The findings show that silicon and strontium can effectively enhance osseointegration through the simultaneous promotion of both angiogenesis and osteogenesis. Therefore, their integration onto the surface of biomaterials can ultimately decrease the incidence of implant failure due to aseptic loosening.

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References

Rath S, Brandl A, Hiller D, Hoppe A, Gbureck U, Horch R . Bioactive copper-doped glass scaffolds can stimulate endothelial cells in co-culture in combination with mesenchymal stem cells. PLoS One. 2014; 9(12):e113319. PMC: 4254617. DOI: 10.1371/journal.pone.0113319. View

Sivaraj K, Adams R . Blood vessel formation and function in bone. Development. 2016; 143(15):2706-15. DOI: 10.1242/dev.136861. View

Hartjen P, Hoffmann A, Henningsen A, Barbeck M, Kopp A, Kluwe L . Plasma Electrolytic Oxidation of Titanium Implant Surfaces: Microgroove-Structures Improve Cellular Adhesion and Viability. In Vivo. 2018; 32(2):241-247. PMC: 5905190. DOI: 10.21873/invivo.11230. View

Weng L, Boda S, Teusink M, Shuler F, Li X, Xie J . Binary Doping of Strontium and Copper Enhancing Osteogenesis and Angiogenesis of Bioactive Glass Nanofibers while Suppressing Osteoclast Activity. ACS Appl Mater Interfaces. 2017; 9(29):24484-24496. DOI: 10.1021/acsami.7b06521. View

Lertkiatmongkol P, Liao D, Mei H, Hu Y, Newman P . Endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31). Curr Opin Hematol. 2016; 23(3):253-9. PMC: 4986701. DOI: 10.1097/MOH.0000000000000239. View

Parithimarkalaignan S, Padmanabhan T . Osseointegration: an update. J Indian Prosthodont Soc. 2014; 13(1):2-6. PMC: 3602536. DOI: 10.1007/s13191-013-0252-z. View

Zong M, Bai L, Liu Y, Wang X, Zhang X, Huang X . Antibacterial ability and angiogenic activity of Cu-Ti-O nanotube arrays. Mater Sci Eng C Mater Biol Appl. 2016; 71:93-99. DOI: 10.1016/j.msec.2016.09.077. View

Potente M, Gerhardt H, Carmeliet P . Basic and therapeutic aspects of angiogenesis. Cell. 2011; 146(6):873-87. DOI: 10.1016/j.cell.2011.08.039. View

Santos-Coquillat A, Esteban-Lucia M, Martinez-Campos E, Mohedano M, Arrabal R, Blawert C . PEO coatings design for Mg-Ca alloy for cardiovascular stent and bone regeneration applications. Mater Sci Eng C Mater Biol Appl. 2019; 105:110026. DOI: 10.1016/j.msec.2019.110026. View

10.

Zhu H, Zhai D, Lin C, Zhang Y, Huan Z, Chang J . 3D plotting of highly uniform Sr(PO)SiO bioceramic scaffolds for bone tissue engineering. J Mater Chem B. 2020; 4(37):6200-6212. DOI: 10.1039/c6tb01692h. View

11.

Walker J, Shadanbaz S, Woodfield T, Staiger M, Dias G . Magnesium biomaterials for orthopedic application: a review from a biological perspective. J Biomed Mater Res B Appl Biomater. 2014; 102(6):1316-31. DOI: 10.1002/jbm.b.33113. View

12.

Chen Y, Gao A, Bai L, Wang Y, Wang X, Zhang X . Antibacterial, osteogenic, and angiogenic activities of SrTiO nanotubes embedded with AgO nanoparticles. Mater Sci Eng C Mater Biol Appl. 2017; 75:1049-1058. DOI: 10.1016/j.msec.2017.03.014. View

13.

Hamdy N . Strontium ranelate improves bone microarchitecture in osteoporosis. Rheumatology (Oxford). 2009; 48 Suppl 4:iv9-13. DOI: 10.1093/rheumatology/kep274. View

14.

Lin K, Xia L, Li H, Jiang X, Pan H, Xu Y . Enhanced osteoporotic bone regeneration by strontium-substituted calcium silicate bioactive ceramics. Biomaterials. 2013; 34(38):10028-42. DOI: 10.1016/j.biomaterials.2013.09.056. View

15.

Lin S, Zhang W, Jiang X . Applications of Bioactive Ions in Bone Regeneration. Chin J Dent Res. 2019; 22(2):93-104. DOI: 10.3290/j.cjdr.a42513. View

16.

Kaur G, Dufour J . Cell lines: Valuable tools or useless artifacts. Spermatogenesis. 2012; 2(1):1-5. PMC: 3341241. DOI: 10.4161/spmg.19885. View

17.

Moses J, Dey M, Bavya Devi K, Roy M, Nandi S, Mandal B . Synergistic Effects of Silicon/Zinc Doped Brushite and Silk Scaffolding in Augmenting the Osteogenic and Angiogenic Potential of Composite Biomimetic Bone Grafts. ACS Biomater Sci Eng. 2021; 5(3):1462-1475. DOI: 10.1021/acsbiomaterials.8b01350. View

18.

He X, Zhang X, Li J, Hang R, Huang X, Yao X . Titanium-based implant comprising a porous microstructure assembled with nanoleaves and controllable silicon-ion release for enhanced osseointegration. J Mater Chem B. 2020; 6(31):5100-5114. DOI: 10.1039/c8tb00713f. View

19.

Dashnyam K, Jin G, Kim J, Perez R, Jang J, Kim H . Promoting angiogenesis with mesoporous microcarriers through a synergistic action of delivered silicon ion and VEGF. Biomaterials. 2016; 116:145-157. DOI: 10.1016/j.biomaterials.2016.11.053. View

20.

Oryan A, Monazzah S, Bigham-Sadegh A . Bone injury and fracture healing biology. Biomed Environ Sci. 2015; 28(1):57-71. DOI: 10.3967/bes2015.006. View