Pathogenesis and Characteristics of Large Ameloblastoma of the Jaw: a Report of Two Rare Cases

Overview

Journal J Int Med Res

Publisher Sage Publications

Specialty General Medicine

Date 2021 May 26

PMID 34034548

Authors

Xue Qiao

Xing Niu

Jiayi Liu

Lijie Chen

Yan Guo

Ming Zhong

Affiliations

Soon will be listed here.

Abstract

Ameloblastoma is a common odontogenic epithelial tumor that exhibits various biological behaviors, ranging from simple cystic expansion to aggressive solid masses characterized by local invasiveness, a high risk of recurrence, and even malignant transformation. We report on two cases of unusually large solid ameloblastomas. We detected epithelial-mesenchymal transition-related gene expression and gene single nucleotide polymorphisms, providing possible molecular evidence of mesenchymal morphological changes in ameloblastoma. The detailed analysis of the pathogenesis of these two cases of ameloblastoma may deepen our understanding of this rare disease and offer promising targets for future targeted therapy.

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