Orbital Invasion of Ameloblastoma: A Systematic Review Apropos of a Rare Entity

Overview

Journal J Curr Ophthalmol

Date 2018 Mar 23

PMID 29564405

Citations 4

Authors

Mohammad-Ali Abtahi

Alireza Zandi

Hassan Razmjoo

Sara Ghaffari

Seyed-Mojtaba Abtahi

Hamidreza Jahanbani-Ardakani

Zahra Kasaei

Samira Kasaei-Koupaei

Sepideh Sajjadi

Seyed-Ali Sonbolestan

Seyed-Hossein Abtahi

Affiliations

Soon will be listed here.

Abstract

Purpose: Ameloblastoma is a non-encapsulated and slow-growing tumor with high recurrence rate. Orbital involvement by this neoplasm is an extremely rare entity. In this study, we present a systematic review on this situation along with clinical and paraclinical features of a case.

Methods: An electronic search was conducted on major medical sources. Data of the cases in the literature in addition to our own case were extracted, summarized, and statistically analyzed.

Results: A total of 36 other cases from 20 relevant studies were also reviewed. Review topics included epidemiology, clinical presentation, pathologic features, differential diagnosis, imaging, treatment, and prognosis. We provided a five-year history of a 50-year-old man with orbital/skull base invasion of plexiform maxillary ameloblastoma.

Conclusions: Maxillary ameloblastoma is a locally aggressive neoplasm, and physicians must be alert to the biologic behavior of this tumor to detect any invasion to critical structures such as orbit and cranium. Orbital ameloblastoma causes significant morbidity and mortality. We advocate meticulous patient follow-up with regular clinical examinations and paraclinical work-up for timely detection of any invasion or recurrence. The best must be done to avoid extensions by aggressive removal of maxillary ameloblastoma.

Citing Articles

Dentigerous Cyst Masquerading as Lacrimal Sac Diverticulitis.

Doctor S, Agarwal A, Ali M, Bothra N Case Rep Ophthalmol. 2025; 16(1):95-101.

PMID: 39981541 PMC: 11842074. DOI: 10.1159/000543279.

Maxillary Ameloblastoma with Local Recurrence, Orbital Invasion, and Systemic Metastases: A Case Report and Review of the Literature.

Linaburg T, Araya J, Briceno C Case Rep Ophthalmol. 2024; 15(1):238-245.

PMID: 38504671 PMC: 10950358. DOI: 10.1159/000537707.

Implant-supported prosthetic rehabilitation after Ameloblastomas treatment: a systematic review.

Alarcon-Sanchez M, Becerra-Ruiz J, Yessayan L, Mosaddad S, Heboyan A BMC Oral Health. 2023; 23(1):1013.

PMID: 38110933 PMC: 10729555. DOI: 10.1186/s12903-023-03765-7.

Pathogenesis and characteristics of large ameloblastoma of the jaw: a report of two rare cases.

Qiao X, Niu X, Liu J, Chen L, Guo Y, Zhong M J Int Med Res. 2021; 49(5):3000605211014803.

PMID: 34034548 PMC: 8161878. DOI: 10.1177/03000605211014803.

Maxillary Ameloblastoma: A Review With Clinical, Histological and Prognostic Data of a Rare Tumor.

Evangelou Z, Zarachi A, Dumollard J, Peoch M, Komnos I, Kastanioudakis I In Vivo. 2020; 34(5):2249-2258.

PMID: 32871747 PMC: 7652510. DOI: 10.21873/invivo.12035.

References

Brazis P, Miller N, Lee A, Holliday M . Neuro-ophthalmologic Aspects of Ameloblastoma. Skull Base Surg. 1995; 5(4):233-44. PMC: 1656531. DOI: 10.1055/s-2008-1058921. View

Sehdev M, Huvos A, Strong E, GEROLD F, Willis G . Proceedings: Ameloblastoma of maxilla and mandible. Cancer. 1974; 33(2):324-33. DOI: 10.1002/1097-0142(197402)33:2<324::aid-cncr2820330205>3.0.co;2-u. View

Ackermann G, Altini M, Shear M . The unicystic ameloblastoma: a clinicopathological study of 57 cases. J Oral Pathol. 1988; 17(9-10):541-6. DOI: 10.1111/j.1600-0714.1988.tb01331.x. View

Kaye F, Ivey A, Drane W, Mendenhall W, Allan R . Clinical and radiographic response with combined BRAF-targeted therapy in stage 4 ameloblastoma. J Natl Cancer Inst. 2014; 107(1):378. DOI: 10.1093/jnci/dju378. View

Ciment L, Ciment A . Malignant ameloblastoma metastatic to the lungs 29 years after primary resection: a case report. Chest. 2002; 121(4):1359-61. DOI: 10.1378/chest.121.4.1359. View

Milman T, Lee V, LiVolsi V . Maxillary Ameloblastoma with Orbital Involvement: An Institutional Experience and Literature Review. Ophthalmic Plast Reconstr Surg. 2015; 32(6):441-446. PMC: 5514419. DOI: 10.1097/IOP.0000000000000580. View

Mosadomi A . Odontogenic tumors in an African population. Analysis of twenty-nine cases seen over a 5-year period. Oral Surg Oral Med Oral Pathol. 1975; 40(4):502-21. DOI: 10.1016/0030-4220(75)90248-0. View

Garcia Reija M, Izquierdo M, Rueda J, Garcia Cantera M, Verrier Hernandez A . [Maxillary ameloblastoma: report of two cases]. Acta Otorrinolaringol Esp. 2001; 52(3):261-5. DOI: 10.1016/s0001-6519(01)78206-4. View

Becelli R, Carboni A, Cerulli G, Perugini M, Iannetti G . Mandibular ameloblastoma: analysis of surgical treatment carried out in 60 patients between 1977 and 1998. J Craniofac Surg. 2002; 13(3):395-400; discussion 400. DOI: 10.1097/00001665-200205000-00006. View

10.

Cohen M, Hertzanu Y, Mendelsohn D . Computed tomography in the diagnosis and treatment of mandibular ameloblastoma: report of cases. J Oral Maxillofac Surg. 1985; 43(10):796-800. DOI: 10.1016/0278-2391(85)90338-6. View

11.

Lu Y, Xuan M, Takata T, Wang C, He Z, Zhou Z . Odontogenic tumors. A demographic study of 759 cases in a Chinese population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998; 86(6):707-14. DOI: 10.1016/s1079-2104(98)90208-6. View

12.

Daramola J, Abioye A, Ajagbe H, Aghadiuno P . Maxillary malignant ameloblastoma with intraorbital extension: report of case. J Oral Surg. 1980; 38(3):203-6. View

13.

Kyriazis A, Karkazis G, Kyriazis A . Maxillary ameloblastoma with intracerebral extension. Report of a case. Oral Surg Oral Med Oral Pathol. 1971; 32(4):582-7. DOI: 10.1016/0030-4220(71)90323-9. View

14.

Shaw H, Katsikas D . Ameloblastoma of the maxilla. A clinical study with four cases. J Laryngol Otol. 1973; 87(9):873-84. DOI: 10.1017/s0022215100077744. View

15.

Bredenkamp J, Zimmerman M, Mickel R . Maxillary ameloblastoma. A potentially lethal neoplasm. Arch Otolaryngol Head Neck Surg. 1989; 115(1):99-104. DOI: 10.1001/archotol.1989.01860250101036. View

16.

OBrien C, LEINFELDER P . Unilateral Exophthalmos: Etiologic and Diagnostic Studies in Eighty-two Consecutive Cases. Trans Am Ophthalmol Soc. 1934; 32:324-40. PMC: 1315480. View

17.

Ally M, Tang J, Joseph T, Thompson B, Lindgren J, Raphael M . The use of vismodegib to shrink keratocystic odontogenic tumors in patients with basal cell nevus syndrome. JAMA Dermatol. 2014; 150(5):542-5. PMC: 4024084. DOI: 10.1001/jamadermatol.2013.7444. View

18.

Herwig M, Fischer H, Moore C, Walsh M, Olson J, Beitler J . [Orbital invasion of a maxillary ameloblastoma]. Ophthalmologe. 2012; 110(3):251-4. DOI: 10.1007/s00347-012-2622-z. View

19.

Reichart P, Philipsen H, Sonner S . Ameloblastoma: biological profile of 3677 cases. Eur J Cancer B Oral Oncol. 1995; 31B(2):86-99. DOI: 10.1016/0964-1955(94)00037-5. View

20.

Dunfee B, Sakai O, Pistey R, Gohel A . Radiologic and pathologic characteristics of benign and malignant lesions of the mandible. Radiographics. 2006; 26(6):1751-68. DOI: 10.1148/rg.266055189. View