Targeting the Glycans: A Paradigm for Host-targeted and COVID-19 Drug Design

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2021 May 24

PMID 34028178

Citations 4

Authors

Fatemeh Pourrajab

Affiliations

Soon will be listed here.

Abstract

There is always a need for new approaches for the control of virus burdens caused by seasonal outbreaks, the emergence of novel viruses with pandemic potential and the development of resistance to current antiviral drugs. The outbreak of the 2019 novel coronavirus-disease COVID-19 represented a pandemic threat and declared a public health emergency of international concern. Herein, the role of glycans for the development of new drugs or vaccines, as a host-targeted approach, is discussed where may provide a front-line prophylactic or threats to protect against the current and any future respiratory-infecting virus and possibly against other respiratory pathogens. As a prototype, the role of glycans in the coronavirus infection, as well as, galectins (Gal) as the glycan-recognition agents (GRAs) in drug design are here summarized. Galectins, in particular, Gal-1 and Gal-3 are ubiquitous and important to biological systems, whose interactions with viral glycans modulate host immunity and homeostatic balance.

Citing Articles

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The emergence of SARS-CoV-2 variants of concern in Australia by haplotype coalescence reveals a continental link to COVID-19 seasonality.

Tomaszewski T, Gurtler V, Caetano-Anolles K, Caetano-Anolles G Methods Microbiol. 2023; 50:233-268.

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Seasonal effects decouple SARS-CoV-2 haplotypes worldwide.

Tomaszewski T, Ali M, Caetano-Anolles K, Caetano-Anolles G F1000Res. 2023; 12:267.

PMID: 37069849 PMC: 10105261. DOI: 10.12688/f1000research.131522.1.

Targeting the glycans: A paradigm for host-targeted and COVID-19 drug design.

Pourrajab F J Cell Mol Med. 2021; .

PMID: 34028178 PMC: 8242448. DOI: 10.1111/jcmm.16585.

References

Balzarini J . Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy. Nat Rev Microbiol. 2007; 5(8):583-97. PMC: 7098186. DOI: 10.1038/nrmicro1707. View

Xiong X, Tortorici M, Snijder J, Yoshioka C, Walls A, Li W . Glycan Shield and Fusion Activation of a Deltacoronavirus Spike Glycoprotein Fine-Tuned for Enteric Infections. J Virol. 2017; 92(4). PMC: 5790929. DOI: 10.1128/JVI.01628-17. View

Chen Y, Wang S, Weng I, Hong M, Lo T, Jan J . Galectin-3 Enhances Avian H5N1 Influenza A Virus-Induced Pulmonary Inflammation by Promoting NLRP3 Inflammasome Activation. Am J Pathol. 2018; 188(4):1031-1042. DOI: 10.1016/j.ajpath.2017.12.014. View

Varki A, Gagneux P . Multifarious roles of sialic acids in immunity. Ann N Y Acad Sci. 2012; 1253:16-36. PMC: 3357316. DOI: 10.1111/j.1749-6632.2012.06517.x. View

Watanabe Y, Berndsen Z, Raghwani J, Seabright G, Allen J, Pybus O . Vulnerabilities in coronavirus glycan shields despite extensive glycosylation. Nat Commun. 2020; 11(1):2688. PMC: 7253482. DOI: 10.1038/s41467-020-16567-0. View

Vankadari N, Wilce J . Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26. Emerg Microbes Infect. 2020; 9(1):601-604. PMC: 7103712. DOI: 10.1080/22221751.2020.1739565. View

Peng G, Xu L, Lin Y, Chen L, Pasquarella J, Holmes K . Crystal structure of bovine coronavirus spike protein lectin domain. J Biol Chem. 2012; 287(50):41931-8. PMC: 3516740. DOI: 10.1074/jbc.M112.418210. View

Connaris H, Govorkova E, Ligertwood Y, Dutia B, Yang L, Tauber S . Prevention of influenza by targeting host receptors using engineered proteins. Proc Natl Acad Sci U S A. 2014; 111(17):6401-6. PMC: 4035977. DOI: 10.1073/pnas.1404205111. View

Pretini V, Koenen M, Kaestner L, Fens M, Schiffelers R, Bartels M . Red Blood Cells: Chasing Interactions. Front Physiol. 2019; 10:945. PMC: 6684843. DOI: 10.3389/fphys.2019.00945. View

10.

Nicholls J, Bourne A, Chen H, Guan Y, Peiris J . Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses. Respir Res. 2007; 8:73. PMC: 2169242. DOI: 10.1186/1465-9921-8-73. View

11.

Gautret P, Lagier J, Parola P, Hoang V, Meddeb L, Mailhe M . RETRACTED: Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 2020; 56(1):105949. PMC: 7102549. DOI: 10.1016/j.ijantimicag.2020.105949. View

12.

Zhou P, Yang X, Wang X, Hu B, Zhang L, Zhang W . A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579(7798):270-273. PMC: 7095418. DOI: 10.1038/s41586-020-2012-7. View

13.

Chen W, Cao Z, Leffler H, Nilsson U, Panjwani N . Galectin-3 Inhibition by a Small-Molecule Inhibitor Reduces Both Pathological Corneal Neovascularization and Fibrosis. Invest Ophthalmol Vis Sci. 2017; 58(1):9-20. PMC: 5225999. DOI: 10.1167/iovs.16-20009. View

14.

Wrapp D, Wang N, Corbett K, Goldsmith J, Hsieh C, Abiona O . Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020; 367(6483):1260-1263. PMC: 7164637. DOI: 10.1126/science.abb2507. View

15.

Park Y, Walls A, Wang Z, Sauer M, Li W, Tortorici M . Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors. Nat Struct Mol Biol. 2019; 26(12):1151-1157. PMC: 7097669. DOI: 10.1038/s41594-019-0334-7. View

16.

Izquierdo-Useros N, Lorizate M, McLaren P, Telenti A, Krausslich H, Martinez-Picado J . HIV-1 capture and transmission by dendritic cells: the role of viral glycolipids and the cellular receptor Siglec-1. PLoS Pathog. 2014; 10(7):e1004146. PMC: 4102576. DOI: 10.1371/journal.ppat.1004146. View

17.

Lu R, Zhao X, Li J, Niu P, Yang B, Wu H . Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020; 395(10224):565-574. PMC: 7159086. DOI: 10.1016/S0140-6736(20)30251-8. View

18.

Ruscitti P, Cipriani P, Di Benedetto P, Liakouli V, Berardicurti O, Carubbi F . H-ferritin and proinflammatory cytokines are increased in the bone marrow of patients affected by macrophage activation syndrome. Clin Exp Immunol. 2017; 191(2):220-228. PMC: 5758371. DOI: 10.1111/cei.13057. View

19.

Vasta G . Galectins as pattern recognition receptors: structure, function, and evolution. Adv Exp Med Biol. 2011; 946:21-36. PMC: 3429938. DOI: 10.1007/978-1-4614-0106-3_2. View

20.

Zhou D, Dai S, Tong Q . COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression. J Antimicrob Chemother. 2020; 75(7):1667-1670. PMC: 7184499. DOI: 10.1093/jac/dkaa114. View