DNA Origami Single Crystals with Wulff Shapes

Overview

Journal Nat Commun

Specialty Biology

Date 2021 May 22

PMID 34021131

Citations 16

Authors

Yong Wang

Lizhi Dai

Zhiyuan Ding

Min Ji

Jiliang Liu

Hang Xing

Xiaoguo Liu

Yonggang Ke

Chunhai Fan

Peng Wang

Ye Tian

Affiliations

Soon will be listed here.

Abstract

DNA origami technology has proven to be an excellent tool for precisely manipulating molecules and colloidal elements in a three-dimensional manner. However, fabrication of single crystals with well-defined facets from highly programmable, complex DNA origami units is a great challenge. Here, we report the successful fabrication of DNA origami single crystals with Wulff shapes and high yield. By regulating the symmetries and binding modes of the DNA origami building blocks, the crystalline shapes can be designed and well-controlled. The single crystals are then used to induce precise growth of an ultrathin layer of silica on the edges, resulting in mechanically reinforced silica-DNA hybrid structures that preserve the details of the single crystals without distortion. The silica-infused microcrystals can be directly observed in the dry state, which allows meticulous analysis of the crystal facets and tomographic 3D reconstruction of the single crystals by high-resolution electron microscopy.

Citing Articles

Generative design-enabled exploration of wireframe DNA origami nanostructures.

Vetturini A, Cagan J, Taylor R Nucleic Acids Res. 2024; 53(2.

PMID: 39739844 PMC: 11754647. DOI: 10.1093/nar/gkae1268.

DNA origami-designed 3D phononic crystals.

Park S, Park H, Nam J, Ke Y, Liedl T, Tian Y Nanophotonics. 2024; 12(13):2611-2621.

PMID: 39633742 PMC: 11501301. DOI: 10.1515/nanoph-2023-0024.

Crystalline Assemblies of DNA Nanostructures and Their Functional Properties.

Li X, Wang J, Baptist A, Wu W, Heuer-Jungemann A, Zhang T Angew Chem Int Ed Engl. 2024; 64(3):e202416948.

PMID: 39576670 PMC: 11735872. DOI: 10.1002/anie.202416948.

Recycling Materials for Sustainable DNA Origami Manufacturing.

Neuhoff M, Wang Y, Vantangoli N, Poirier M, Castro C, Pfeifer W Nano Lett. 2024; 24(39):12080-12087.

PMID: 39315689 PMC: 11451448. DOI: 10.1021/acs.nanolett.4c02695.

Symmetry-Guided Inverse Design of Self-Assembling Multiscale DNA Origami Tilings.

Hayakawa D, Videbaek T, Grason G, Rogers W ACS Nano. 2024; 18(29):19169-19178.

PMID: 38981100 PMC: 11271658. DOI: 10.1021/acsnano.4c04515.

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