Recent Advances in DNA Origami-Engineered Nanomaterials and Applications

Overview

Journal Chem Rev

Publisher American Chemical Society

Specialty Chemistry

Date 2023 Mar 29

PMID 36990451

Authors

Pengfei Zhan

Andreas Peil

Qiao Jiang

Dongfang Wang

Shikufa Mousavi

Qiancheng Xiong

Qi Shen

Yingxu Shang

Baoquan Ding

Chenxiang Lin

Yonggang Ke

Na Liu

Affiliations

Soon will be listed here.

Abstract

DNA nanotechnology is a unique field, where physics, chemistry, biology, mathematics, engineering, and materials science can elegantly converge. Since the original proposal of Nadrian Seeman, significant advances have been achieved in the past four decades. During this glory time, the DNA origami technique developed by Paul Rothemund further pushed the field forward with a vigorous momentum, fostering a plethora of concepts, models, methodologies, and applications that were not thought of before. This review focuses on the recent progress in DNA origami-engineered nanomaterials in the past five years, outlining the exciting achievements as well as the unexplored research avenues. We believe that the spirit and assets that Seeman left for scientists will continue to bring interdisciplinary innovations and useful applications to this field in the next decade.

Citing Articles

Tailoring DNA Origami Protection: A Study of Oligolysine-PEG Coatings for Improved Colloidal, Structural, and Functional Integrity.

Rodriguez-Franco H, Hendrickx P, Bastings M ACS Polym Au. 2025; 5(1):35-44.

PMID: 39958528 PMC: 11826485. DOI: 10.1021/acspolymersau.4c00085.

Multifunctional DNA-Collagen Biomaterials: Developmental Advances and Biomedical Applications.

Pipis N, James B, Allen J ACS Biomater Sci Eng. 2025; 11(3):1253-1268.

PMID: 39869382 PMC: 11897955. DOI: 10.1021/acsbiomaterials.4c01475.

Research Progress in Small-Molecule Detection Using Aptamer-Based SERS Techniques.

Zheng L, Ye Q, Wang M, Sun F, Chen Q, Yu X Biosensors (Basel). 2025; 15(1).

PMID: 39852080 PMC: 11764255. DOI: 10.3390/bios15010029.

Autonomous Nucleic Acid and Protein Nanocomputing Agents Engineered to Operate in Living Cells.

Panigaj M, Basu Roy T, Skelly E, Chandler M, Wang J, Ekambaram S ACS Nano. 2025; 19(2):1865-1883.

PMID: 39760461 PMC: 11757000. DOI: 10.1021/acsnano.4c13663.

DNA-Mediated Carbon Nanotubes Heterojunction Assembly.

Mengrani Z, Hong W, Palma M ACS Nanosci Au. 2024; 4(6):391-398.

PMID: 39713723 PMC: 11659895. DOI: 10.1021/acsnanoscienceau.4c00025.

References

Cha T, Pan J, Chen H, Salgado J, Li X, Mao C . A synthetic DNA motor that transports nanoparticles along carbon nanotubes. Nat Nanotechnol. 2013; 9(1):39-43. DOI: 10.1038/nnano.2013.257. View

Zhan P, Urban M, Both S, Duan X, Kuzyk A, Weiss T . DNA-assembled nanoarchitectures with multiple components in regulated and coordinated motion. Sci Adv. 2019; 5(11):eaax6023. PMC: 6884410. DOI: 10.1126/sciadv.aax6023. View

Dietz H, Douglas S, Shih W . Folding DNA into twisted and curved nanoscale shapes. Science. 2009; 325(5941):725-30. PMC: 2737683. DOI: 10.1126/science.1174251. View

Fang W, Jia S, Chao J, Wang L, Duan X, Liu H . Quantizing single-molecule surface-enhanced Raman scattering with DNA origami metamolecules. Sci Adv. 2019; 5(9):eaau4506. PMC: 6764828. DOI: 10.1126/sciadv.aau4506. View

Kershner R, Bozano L, Micheel C, Hung A, Fornof A, Cha J . Placement and orientation of individual DNA shapes on lithographically patterned surfaces. Nat Nanotechnol. 2009; 4(9):557-61. DOI: 10.1038/nnano.2009.220. View

Xu Z, Huang Y, Yin H, Zhu X, Tian Y, Min Q . DNA Origami-Based Protein Manipulation Systems: From Function Regulation to Biological Application. Chembiochem. 2021; 23(9):e202100597. DOI: 10.1002/cbic.202100597. View

Brown J, Alford R, Walsh J, Spinney R, Xu S, Hertel S . Rapid Exchange of Stably Bound Protein and DNA Cargo on a DNA Origami Receptor. ACS Nano. 2022; 16(4):6455-6467. DOI: 10.1021/acsnano.2c00699. View

Kuzyk A, Schreiber R, Zhang H, Govorov A, Liedl T, Liu N . Reconfigurable 3D plasmonic metamolecules. Nat Mater. 2014; 13(9):862-6. DOI: 10.1038/nmat4031. View

Schmid S, Stommer P, Dietz H, Dekker C . Nanopore electro-osmotic trap for the label-free study of single proteins and their conformations. Nat Nanotechnol. 2021; 16(11):1244-1250. DOI: 10.1038/s41565-021-00958-5. View

10.

Veneziano R, Moyer T, Stone M, Wamhoff E, Read B, Mukherjee S . Role of nanoscale antigen organization on B-cell activation probed using DNA origami. Nat Nanotechnol. 2020; 15(8):716-723. PMC: 7415668. DOI: 10.1038/s41565-020-0719-0. View

11.

Ke Y, Liu Y, Zhang J, Yan H . A study of DNA tube formation mechanisms using 4-, 8-, and 12-helix DNA nanostructures. J Am Chem Soc. 2006; 128(13):4414-21. DOI: 10.1021/ja058145z. View

12.

Zhang P, Liu X, Liu P, Wang F, Ariyama H, Ando T . Capturing transient antibody conformations with DNA origami epitopes. Nat Commun. 2020; 11(1):3114. PMC: 7305102. DOI: 10.1038/s41467-020-16949-4. View

13.

Jun H, Wang X, Parsons M, Bricker W, John T, Li S . Rapid prototyping of arbitrary 2D and 3D wireframe DNA origami. Nucleic Acids Res. 2021; 49(18):10265-10274. PMC: 8501967. DOI: 10.1093/nar/gkab762. View

14.

Suzuki Y, Endo M, Yang Y, Sugiyama H . Dynamic assembly/disassembly processes of photoresponsive DNA origami nanostructures directly visualized on a lipid membrane surface. J Am Chem Soc. 2014; 136(5):1714-7. DOI: 10.1021/ja4109819. View

15.

Shetty R, Brady S, Rothemund P, Hariadi R, Gopinath A . Bench-Top Fabrication of Single-Molecule Nanoarrays by DNA Origami Placement. ACS Nano. 2021; 15(7):11441-11450. PMC: 9701110. DOI: 10.1021/acsnano.1c01150. View

16.

Schmied J, Gietl A, Holzmeister P, Forthmann C, Steinhauer C, Dammeyer T . Fluorescence and super-resolution standards based on DNA origami. Nat Methods. 2012; 9(12):1133-4. DOI: 10.1038/nmeth.2254. View

17.

Sun Y, Sun J, Xiao M, Lai W, Li L, Fan C . DNA origami-based artificial antigen-presenting cells for adoptive T cell therapy. Sci Adv. 2022; 8(48):eadd1106. PMC: 10936057. DOI: 10.1126/sciadv.add1106. View

18.

Cangialosi A, Yoon C, Liu J, Huang Q, Guo J, Nguyen T . DNA sequence-directed shape change of photopatterned hydrogels via high-degree swelling. Science. 2017; 357(6356):1126-1130. DOI: 10.1126/science.aan3925. View

19.

Neubrech F, Hentschel M, Liu N . Reconfigurable Plasmonic Chirality: Fundamentals and Applications. Adv Mater. 2020; 32(41):e1905640. DOI: 10.1002/adma.201905640. View

20.

Bath J, Green S, Turberfield A . A free-running DNA motor powered by a nicking enzyme. Angew Chem Int Ed Engl. 2005; 44(28):4358-61. DOI: 10.1002/anie.200501262. View