Myeloid-derived Growth Factor Inhibits Inflammation and Alleviates Endothelial Injury and Atherosclerosis in Mice

Overview

Journal Sci Adv

Specialties Biology
Science

Date 2021 May 22

PMID 34020949

Citations 30

Authors

Biying Meng

Yixiang Li

Yan Ding

Xiaoli Xu

Li Wang

Bei Guo

Biao Zhu

Jiajia Zhang

Lin Xiang

Jing Dong

Min Liu

Lingwei Xiang

Guangda Xiang

Affiliations

Soon will be listed here.

Abstract

Whether bone marrow modulates systemic metabolism remains unknown. Here, we found that (i) myeloid cell-specific myeloid-derived growth factor (MYDGF) deficiency exacerbated vascular inflammation, adhesion responses, endothelial injury, and atherosclerosis in vivo. (ii) Myeloid cell-specific MYDGF restoration attenuated vascular inflammation, adhesion responses and leukocyte homing and alleviated endothelial injury and atherosclerosis in vivo. (iii) MYDGF attenuated endothelial inflammation, apoptosis, permeability, and adhesion responses induced by palmitic acid in vitro. (iv) MYDGF alleviated endothelial injury and atherosclerosis through mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)/nuclear factor κB (NF-κB) signaling. Therefore, we concluded that MYDGF inhibits endothelial inflammation and adhesion responses, blunts leukocyte homing, protects against endothelial injury and atherosclerosis in a manner involving MAP4K4/NF-κB signaling, and serves as a cross-talk factor between bone marrow and arteries to regulate the pathophysiology of arteries. Bone marrow functions as an endocrine organ and serves as a potential therapeutic target for metabolic disorders.

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