Bone Physiological Microenvironment and Healing Mechanism: Basis for Future Bone-tissue Engineering Scaffolds

Overview

Journal Bioact Mater

Specialty Biomedical Engineering

Date 2021 May 17

PMID 33997497

Citations 139

Authors

Guanyin Zhu

Tianxu Zhang

Miao Chen

Ke Yao

Xinqi Huang

Bo Zhang

Yazhen Li

Jun Liu

Yunbing Wang

Zhihe Zhao

Affiliations

Soon will be listed here.

Abstract

Bone-tissue defects affect millions of people worldwide. Despite being common treatment approaches, autologous and allogeneic bone grafting have not achieved the ideal therapeutic effect. This has prompted researchers to explore novel bone-regeneration methods. In recent decades, the development of bone tissue engineering (BTE) scaffolds has been leading the forefront of this field. As researchers have provided deep insights into bone physiology and the bone-healing mechanism, various biomimicking and bioinspired BTE scaffolds have been reported. Now it is necessary to review the progress of natural bone physiology and bone healing mechanism, which will provide more valuable enlightenments for researchers in this field. This work details the physiological microenvironment of the natural bone tissue, bone-healing process, and various biomolecules involved therein. Next, according to the bone physiological microenvironment and the delivery of bioactive factors based on the bone-healing mechanism, it elaborates the biomimetic design of a scaffold, highlighting the designing of BTE scaffolds according to bone biology and providing the rationale for designing next-generation BTE scaffolds that conform to natural bone healing and regeneration.

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