Collagen-Based Nanoparticles As Drug Delivery System in Wound Healing Applications

Overview

Journal Int J Nanomedicine

Publisher Dove Medical Press

Specialty Biotechnology

Date 2024 Nov 11

PMID 39524919

Authors

Kusnadi Kusnadi

Yedi Herdiana

Emma Rochima

Okta Nama Putra

Amirah Mohd Gazzali

Muchtaridi Muchtaridi

Affiliations

Soon will be listed here.

Abstract

Background: Conventional wound dressings often adhere to wounds and can cause secondary injury due to their lack of anti-inflammatory and antibacterial properties. In contrast, collagen-based nanoparticles (NPs) as drug delivery systems exhibit both biocompatibility and biodegradability, presenting a promising avenue for accelerating wound healing processes.

Aims Of Study: This review aims to provide a comprehensive overview of the mechanisms involved in wound healing, description of the attributes of ideal wound dressings, understanding of wound healing efficacy of collagen, exploring NPs-mediated drug delivery mechanisms in wound therapy, detailing the synthesis and fabrication techniques of collagen-based NPs, and delineating the applications of various collagen-based NPs infused wound dressings on wound healing.

Methodology: This review synthesizes relevant literature from reputable databases such as Scopus, Science Direct, Google Scholar, and PubMed.

Results: A diverse array of collagen-based NPs, including nanopolymers, metal NPs, nanoemulsions, nanoliposomes, and nanofibers, demonstrate pronounced efficacy in promoting wound closure and tissue regeneration. The incorporation of collagen-based NPs has not only become an agent for the delivery of therapeutics but also actively contributes to the wound healing cascade.

Conclusion: In conclusion, In brief, the use of collagen-based NPs presents a compelling strategy for expediting wound healing processes.

Citing Articles

Bioadhesive Nanoparticles in Topical Drug Delivery: Advances, Applications, and Potential for Skin Disorder Treatments.

Almuqbil R, Aldhubiab B Pharmaceutics. 2025; 17(2).

PMID: 40006596 PMC: 11860006. DOI: 10.3390/pharmaceutics17020229.

References

Gostynska N, Pannella M, Rocco M, Giardino L, Aloe L, Calza L . The pleiotropic molecule NGF regulates the in vitro properties of fibroblasts, keratinocytes, and endothelial cells: implications for wound healing. Am J Physiol Cell Physiol. 2019; 318(2):C360-C371. DOI: 10.1152/ajpcell.00180.2019. View

Moaness M, Mabrouk M, Ahmed M, Das D, Beherei H . Novel zinc-silver nanocages for drug delivery and wound healing: Preparation, characterization and antimicrobial activities. Int J Pharm. 2022; 616:121559. DOI: 10.1016/j.ijpharm.2022.121559. View

Wathoni N, Sari D, Suharyani I, Motoyama K, Mohammed A, Cahyanto A . Enhancement of α-Mangostin Wound Healing Ability by Complexation with 2-Hydroxypropyl-β-Cyclodextrin in Hydrogel Formulation. Pharmaceuticals (Basel). 2020; 13(10). PMC: 7600479. DOI: 10.3390/ph13100290. View

Duckworth P, Rowlands R, Barbour M, Maddocks S . A novel flow-system to establish experimental biofilms for modelling chronic wound infection and testing the efficacy of wound dressings. Microbiol Res. 2018; 215:141-147. DOI: 10.1016/j.micres.2018.07.009. View

Ghosh D, Yaron J, Abedin M, Godeshala S, Kumar S, Kilbourne J . Bioactive nanomaterials kickstart early repair processes and potentiate temporally modulated healing of healthy and diabetic wounds. Biomaterials. 2024; 306:122496. PMC: 11658459. DOI: 10.1016/j.biomaterials.2024.122496. View

Nikfarjam S, Aldubaisi Y, Swami V, Swami V, Xu G, Vaughan M . Polycaprolactone Electrospun Nanofiber Membrane with Skin Graft Containing Collagen and Bandage Containing MgO Nanoparticles for Wound Healing Applications. Polymers (Basel). 2023; 15(9). PMC: 10180917. DOI: 10.3390/polym15092014. View

Portela L, Cahu T, Bezerra T, do Nascimento Santos D, Sousa G, Portela R . Biocompatibility and immunostimulatory properties of fish collagen and shrimp chitosan towards peripheral blood mononuclear cells (PBMCs). Int J Biol Macromol. 2022; 210:282-291. DOI: 10.1016/j.ijbiomac.2022.05.018. View

Moore A, desJardins-Park H, Duoto B, Mascharak S, Murphy M, Irizarry D . Doxycycline Reduces Scar Thickness and Improves Collagen Architecture. Ann Surg. 2018; 272(1):183-193. PMC: 6588503. DOI: 10.1097/SLA.0000000000003172. View

Deng Q, Gao Y, Rui B, Li X, Liu P, Han Z . Double-network hydrogel enhanced by SS31-loaded mesoporous polydopamine nanoparticles: Symphonic collaboration of near-infrared photothermal antibacterial effect and mitochondrial maintenance for full-thickness wound healing in diabetes mellitus. Bioact Mater. 2023; 27:409-428. PMC: 10160601. DOI: 10.1016/j.bioactmat.2023.04.004. View

10.

Mitchell M, Billingsley M, Haley R, Wechsler M, Peppas N, Langer R . Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2020; 20(2):101-124. PMC: 7717100. DOI: 10.1038/s41573-020-0090-8. View

11.

Ding Q, Ding C, Liu X, Zheng Y, Zhao Y, Zhang S . Preparation of nanocomposite membranes loaded with taxifolin liposome and its mechanism of wound healing in diabetic mice. Int J Biol Macromol. 2023; 241:124537. DOI: 10.1016/j.ijbiomac.2023.124537. View

12.

He Z, Zhu Y, Ma H, Shen Q, Chen X, Wang X . Hydrogen sulfide regulates macrophage polarization and necroptosis to accelerate diabetic skin wound healing. Int Immunopharmacol. 2024; 132:111990. DOI: 10.1016/j.intimp.2024.111990. View

13.

Kandhasamy S, Perumal S, Madhan B, Umamaheswari N, Banday J, Perumal P . Synthesis and Fabrication of Collagen-Coated Ostholamide Electrospun Nanofiber Scaffold for Wound Healing. ACS Appl Mater Interfaces. 2017; 9(10):8556-8568. DOI: 10.1021/acsami.6b16488. View

14.

Doodmani S, Bagheri A, Natouri O, Nobakht A, Saghebasl S . Electrospinning-netting of spider-inspired polycaprolactone/collagen nanofiber-nets incorporated with Propolis extract for enhanced wound healing applications. Int J Biol Macromol. 2024; 267(Pt 1):131452. DOI: 10.1016/j.ijbiomac.2024.131452. View

15.

Laghezza Masci V, Taddei A, Courant T, Tezgel O, Navarro F, Giorgi F . Characterization of Collagen/Lipid Nanoparticle-Curcumin Cryostructurates for Wound Healing Applications. Macromol Biosci. 2019; 19(5):e1800446. DOI: 10.1002/mabi.201800446. View

16.

Swetha Menon N, Kamaraj M, Anish Sharmila M, Govarthanan M . Recent progress in polysaccharide and polypeptide based modern moisture-retentive wound dressings. Int J Biol Macromol. 2023; 256(Pt 2):128499. DOI: 10.1016/j.ijbiomac.2023.128499. View

17.

Tripathi G, Park M, Lim H, Lee B . Natural TEMPO oxidized cellulose nano fiber/alginate/dSECM hybrid aerogel with improved wound healing and hemostatic ability. Int J Biol Macromol. 2023; 243:125226. DOI: 10.1016/j.ijbiomac.2023.125226. View

18.

Tort S, Acarturk F, Besikci A . Evaluation of three-layered doxycycline-collagen loaded nanofiber wound dressing. Int J Pharm. 2017; 529(1-2):642-653. DOI: 10.1016/j.ijpharm.2017.07.027. View

19.

Zhou T, Wang N, Xue Y, Ding T, Liu X, Mo X . Electrospun tilapia collagen nanofibers accelerating wound healing via inducing keratinocytes proliferation and differentiation. Colloids Surf B Biointerfaces. 2016; 143:415-422. DOI: 10.1016/j.colsurfb.2016.03.052. View

20.

Li Z, Qian C, Zheng X, Qi X, Bi J, Wang H . Collagen/chitosan/genipin hydrogel loaded with phycocyanin nanoparticles and ND-336 for diabetic wound healing. Int J Biol Macromol. 2024; 266(Pt 1):131220. DOI: 10.1016/j.ijbiomac.2024.131220. View