Oral Insulin Delivery Covalent Organic Frameworks

Overview

Journal Chem Sci

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2021 May 17

PMID 33995999

Citations 18

Authors

Farah Benyettou

Nawel Kaddour

Thirumurugan Prakasam

Gobinda Das

Sudhir Kumar Sharma

Sneha Ann Thomas

Fadia Bekhti-Sari

Jamie Whelan

Mohammed A Alkhalifah

Mostafa Khair

Hassan Traboulsi

Renu Pasricha

Ramesh Jagannathan

Nassima Mokhtari-Soulimane

Felipe Gandara

Ali Trabolsi

Affiliations

Soon will be listed here.

Abstract

With diabetes being the 7th leading cause of death worldwide, overcoming issues limiting the oral administration of insulin is of global significance. The development of imine-linked-covalent organic framework (nCOF) nanoparticles for oral insulin delivery to overcome these delivery barriers is herein reported. A gastro-resistant nCOF was prepared from layered nanosheets with insulin loaded between the nanosheet layers. The insulin-loaded nCOF exhibited insulin protection in digestive fluids as well as glucose-responsive release, and this hyperglycemia-induced release was confirmed in diabetic rats without noticeable toxic effects. This is strong evidence that nCOF-based oral insulin delivery systems could replace traditional subcutaneous injections easing insulin therapy.

Citing Articles

Cationic covalent organic framework for the fluorescent sensing and cooperative adsorption of perfluorooctanoic acid.

Jrad A, Das G, Alkhatib N, Prakasam T, Benyettou F, Varghese S Nat Commun. 2024; 15(1):10490.

PMID: 39622838 PMC: 11612209. DOI: 10.1038/s41467-024-53945-4.

Self-Exfoliated Guanidinium Covalent Organic Nanosheets as High-Capacity Curcumin Carrier.

Sharma A, Sharma D, Lin H, Zhou H, Zhao F Biomimetics (Basel). 2024; 9(11).

PMID: 39590281 PMC: 11592196. DOI: 10.3390/biomimetics9110709.

Efficacy of Oral Nanoparticle-Encapsulated Insulin in Reducing Oxidative Stress and Enhancing Tissue Integrity in a Diabetic Rat Model.

Kaddour N, Benyettou F, Moulai K, Mebarki A, Ghemrawi R, Amir Z Int J Nanomedicine. 2024; 19:10961-10981.

PMID: 39493274 PMC: 11529609. DOI: 10.2147/IJN.S468756.

cRGD-Peptide Modified Covalent Organic Frameworks for Precision Chemotherapy in Triple-Negative Breast Cancer.

Benyettou F, Khair M, Prakasam T, Varghese S, Matouk Z, Alkaabi M ACS Appl Mater Interfaces. 2024; 16(42):56676-56695.

PMID: 39267454 PMC: 11503616. DOI: 10.1021/acsami.4c10812.

Tunable Wettability of a Dual-Faced Covalent Organic Framework Membrane for Enhanced Water Filtration.

Benyettou F, Jrad A, Matouk Z, Prakasam T, Hamoud H, Clet G J Am Chem Soc. 2024; 146(33):23537-23554.

PMID: 39110940 PMC: 11345768. DOI: 10.1021/jacs.4c07559.

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