Anacardium Occidentale L. Leaf Extracts Protect Against Glutamate/HO-Induced Oxidative Toxicity and Induce Neurite Outgrowth: The Involvement of SIRT1/Nrf2 Signaling Pathway and Teneurin 4 Transmembrane Protein

Overview

Journal Front Pharmacol

Date 2021 May 17

PMID 33995025

Citations 14

Authors

Chatrawee Duangjan

Panthakarn Rangsinth

Shaoxiong Zhang

Michael Wink

Tewin Tencomnao

Affiliations

Soon will be listed here.

Abstract

Neurodegenerative diseases are linked to neuronal cell death and neurite outgrowth impairment that are often caused by oxidative stress. Natural products, which have neuroprotective against oxidative stress and neurite outgrowth inducing activity, could be potential candidates for alternative treatment of neurodegenerative diseases. This study aims to investigate the neuroprotective effects and neuritogenesis properties of leaf extracts in cultured neuronal (HT22 and Neuro-2a) cells. We found gallic acid, catechin and quercetin as the main compounds in extracts. The extracts have a protective effect against glutamate/HO-mediated oxidative stress-induced cell toxicity. The gene expression of cellular antioxidant enzymes (SODs, GPx and, GSTs) were up-regulated by this treatment. The treatment also triggered SIRT, Nrf2 proteins as well as the mRNA transcriptions of relevant anti-oxidation genes (NQO1, GCLM, and EAAT3). We demonstrated that the extracts promote antioxidant defense in neuronal cells via the SIRT1/Nrf2 signaling pathway. Moreover, the extracts increase neurite outgrowth and Ten-4 expression in Neuro-2a cells. However, the neuritogenesis properties did not occur, when Ten-4 expression was knocked down by corresponding siRNA. These results suggest that the leaf extracts have an interesting neuritogenesis and neuroprotective potential against glutamate/HO-mediated toxicity and could be a potential therapeutic candidate for neurodegenerative diseases.

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References

Yang E, Kim G, Jun M, Song K . Kaempferol attenuates the glutamate-induced oxidative stress in mouse-derived hippocampal neuronal HT22 cells. Food Funct. 2014; 5(7):1395-402. DOI: 10.1039/c4fo00068d. View

Fukui M, Song J, Choi J, Choi H, Zhu B . Mechanism of glutamate-induced neurotoxicity in HT22 mouse hippocampal cells. Eur J Pharmacol. 2009; 617(1-3):1-11. DOI: 10.1016/j.ejphar.2009.06.059. View

Jung K, Kwak M . The Nrf2 system as a potential target for the development of indirect antioxidants. Molecules. 2010; 15(10):7266-91. PMC: 6259123. DOI: 10.3390/molecules15107266. View

Jin M, Park S, Kim Y, Oh J, Lee S, Park G . The neuroprotective effects of cordycepin inhibit glutamate-induced oxidative and ER stress-associated apoptosis in hippocampal HT22 cells. Neurotoxicology. 2014; 41:102-11. DOI: 10.1016/j.neuro.2014.01.005. View

Bonaterra G, Schwendler A, Huther J, Schwarzbach H, Schwarz A, Kolb C . Neurotrophic, Cytoprotective, and Anti-inflammatory Effects of St. John's Wort Extract on Differentiated Mouse Hippocampal HT-22 Neurons. Front Pharmacol. 2018; 8:955. PMC: 5778116. DOI: 10.3389/fphar.2017.00955. View

Suzuki N, Numakawa T, Chou J, de Vega S, Mizuniwa C, Sekimoto K . Teneurin-4 promotes cellular protrusion formation and neurite outgrowth through focal adhesion kinase signaling. FASEB J. 2013; 28(3):1386-97. PMC: 3929675. DOI: 10.1096/fj.13-241034. View

Peng S, Hou Y, Yao J, Fang J . Activation of Nrf2-driven antioxidant enzymes by cardamonin confers neuroprotection of PC12 cells against oxidative damage. Food Funct. 2017; 8(3):997-1007. DOI: 10.1039/c7fo00054e. View

Muroi H, Kubo I . Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus. J Appl Bacteriol. 1996; 80(4):387-94. DOI: 10.1111/j.1365-2672.1996.tb03233.x. View

Katebi S, Esmaeili A, Ghaedi K, Zarrabi A . Superparamagnetic iron oxide nanoparticles combined with NGF and quercetin promote neuronal branching morphogenesis of PC12 cells. Int J Nanomedicine. 2019; 14:2157-2169. PMC: 6445231. DOI: 10.2147/IJN.S191878. View

10.

Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T . Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from L. in . Oxid Med Cell Longev. 2019; 2019:9012396. PMC: 6589224. DOI: 10.1155/2019/9012396. View

11.

Siddiqui S, Kamal A, Khan F, Jamali K, Saeed Saify Z . Gallic and vanillic acid suppress inflammation and promote myelination in an in vitro mouse model of neurodegeneration. Mol Biol Rep. 2018; 46(1):997-1011. DOI: 10.1007/s11033-018-4557-1. View

12.

Park S, Jin M, An H, Kim K, Ko M, Kim C . Emodin induces neurite outgrowth through PI3K/Akt/GSK-3β-mediated signaling pathways in Neuro2a cells. Neurosci Lett. 2015; 588:101-7. DOI: 10.1016/j.neulet.2015.01.001. View

13.

Prasansuklab A, Meemon K, Sobhon P, Tencomnao T . Ethanolic extract of Streblus asper leaves protects against glutamate-induced toxicity in HT22 hippocampal neuronal cells and extends lifespan of Caenorhabditis elegans. BMC Complement Altern Med. 2017; 17(1):551. PMC: 5745612. DOI: 10.1186/s12906-017-2050-3. View

14.

Gomes Junior A, Islam M, Nicolau L, de Souza L, Araujo T, de Oliveira G . Anti-Inflammatory, Antinociceptive, and Antioxidant Properties of Anacardic Acid in Experimental Models. ACS Omega. 2020; 5(31):19506-19515. PMC: 7424580. DOI: 10.1021/acsomega.0c01775. View

15.

Liang Y, Zou Y, Niu C, Niu Y . Astragaloside IV and ferulic acid synergistically promote neurite outgrowth through Nrf2 activation. Mech Ageing Dev. 2019; 180:70-81. DOI: 10.1016/j.mad.2019.04.002. View

16.

Siracusa R, Fusco R, Peritore A, Cordaro M, DAmico R, Genovese T . The Antioxidant and Anti-Inflammatory Properties of L. Cashew Nuts in a Mouse Model of Colitis. Nutrients. 2020; 12(3). PMC: 7146548. DOI: 10.3390/nu12030834. View

17.

Lam C, Gong A, Lam K, Zhang L, Chen J, Dong T . Jujube-containing herbal decoctions induce neuronal differentiation and the expression of anti-oxidant enzymes in cultured PC12 cells. J Ethnopharmacol. 2016; 188:275-83. DOI: 10.1016/j.jep.2016.05.015. View

18.

Xue F, Huang J, Ding P, Zang H, Kou Z, Li T . Nrf2/antioxidant defense pathway is involved in the neuroprotective effects of Sirt1 against focal cerebral ischemia in rats after hyperbaric oxygen preconditioning. Behav Brain Res. 2016; 309:1-8. DOI: 10.1016/j.bbr.2016.04.045. View

19.

Fusco R, Siracusa R, Peritore A, Gugliandolo E, Genovese T, DAmico R . The Role of Cashew ( L.) Nuts on an Experimental Model of Painful Degenerative Joint Disease. Antioxidants (Basel). 2020; 9(6). PMC: 7346149. DOI: 10.3390/antiox9060511. View

20.

Oiram Filho F, Alcantra D, Rodrigues T, Alexandre E Silva L, de Oliveira Silva E, Zocolo G . Development and Validation of a Reversed Phase HPLC Method for Determination of Anacardic Acids in Cashew (Anacardium occidentale) Nut Shell Liquid. J Chromatogr Sci. 2018; 56(4):300-306. DOI: 10.1093/chromsci/bmx111. View