The Critical Role of Sirt1 in Subarachnoid Hemorrhages: Mechanism and Therapeutic Considerations

Overview

Journal Brain Sci

Publisher MDPI

Date 2023 May 16

PMID 37190639

Authors

Zhonghua Zhang

Cong Liu

Xiaoming Zhou

Xin Zhang

Affiliations

Soon will be listed here.

Abstract

The subarachnoid hemorrhage (SAH) is an important cause of death and long-term disability worldwide. As a nicotinamide adenine dinucleotide-dependent deacetylase, silent information regulator 1 (Sirt1) is a multipotent molecule involved in many pathophysiological processes. A growing number of studies have demonstrated that Sirt1 activation may exert positive effects on SAHs by regulating inflammation, oxidative stress, apoptosis, autophagy, and ferroptosis. Thus, Sirt1 agonists may serve as potential therapeutic drugs for SAHs. In this review, we summarized the current state of our knowledge on the relationship between Sirt1 and SAHs and provided an updated overview of the downstream molecules of Sirt1 in SAHs.

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References

Vergouwen M, Vermeulen M, van Gijn J, Rinkel G, Wijdicks E, Muizelaar J . Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group. Stroke. 2010; 41(10):2391-5. DOI: 10.1161/STROKEAHA.110.589275. View

Wu C, Tsai H, Su Y, Tsai C, Lu Y, Lin C . 2-PMAP Ameliorates Cerebral Vasospasm and Brain Injury after Subarachnoid Hemorrhage by Regulating Neuro-Inflammation in Rats. Cells. 2022; 11(2). PMC: 8773560. DOI: 10.3390/cells11020242. View

Sundaresan N, Pillai V, Wolfgeher D, Samant S, Vasudevan P, Parekh V . The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy. Sci Signal. 2011; 4(182):ra46. DOI: 10.1126/scisignal.2001465. View

Zhang Z, Zhang X, Wu X, Zhang Y, Lu J, Li D . Sirt1 attenuates astrocyte activation via modulating Dnajb1 and chaperone-mediated autophagy after closed head injury. Cereb Cortex. 2022; 32(22):5191-5205. DOI: 10.1093/cercor/bhac007. View

Wang R, Wu Z, Bai L, Liu R, Ba Y, Zhang H . Resveratrol improved hippocampal neurogenesis following lead exposure in rats through activation of SIRT1 signaling. Environ Toxicol. 2021; 36(8):1664-1673. DOI: 10.1002/tox.23162. View

Liu Q, Liu Y, Li Y, Hong Z, Li S, Liu C . PUM2 aggravates the neuroinflammation and brain damage induced by ischemia-reperfusion through the SLC7A11-dependent inhibition of ferroptosis via suppressing the SIRT1. Mol Cell Biochem. 2022; 478(3):609-620. PMC: 9938031. DOI: 10.1007/s11010-022-04534-w. View

Qin N, Huang L, Dong R, Li F, Tang X, Zeng Z . [Polydatin improves intestinal barrier injury after traumatic brain injury in rats by reducing oxidative stress and inflammatory response activating SIRT1-mediated deacetylation of SOD2 and HMGB1]. Nan Fang Yi Ke Da Xue Xue Bao. 2022; 42(1):93-100. PMC: 8901389. DOI: 10.12122/j.issn.1673-4254.2022.01.11. View

Jiang Y, Luo Z, Gong Y, Fu Y, Luo Y . NAD supplementation limits triple-negative breast cancer metastasis via SIRT1-P66Shc signaling. Oncogene. 2023; 42(11):808-824. DOI: 10.1038/s41388-023-02592-y. View

Loch Macdonald R . Delayed neurological deterioration after subarachnoid haemorrhage. Nat Rev Neurol. 2013; 10(1):44-58. DOI: 10.1038/nrneurol.2013.246. View

10.

Zhao Y, Jiang Q, Zhang X, Zhu X, Dong X, Shen L . l-Arginine Alleviates LPS-Induced Oxidative Stress and Apoptosis via Activating SIRT1-AKT-Nrf2 and SIRT1-FOXO3a Signaling Pathways in C2C12 Myotube Cells. Antioxidants (Basel). 2021; 10(12). PMC: 8750292. DOI: 10.3390/antiox10121957. View

11.

Nogueiras R, Habegger K, Chaudhary N, Finan B, Banks A, Dietrich M . Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev. 2012; 92(3):1479-514. PMC: 3746174. DOI: 10.1152/physrev.00022.2011. View

12.

Anderson F, Biggs K, Rankin B, Havrda M . NLRP3 inflammasome in neurodegenerative disease. Transl Res. 2022; 252:21-33. PMC: 10614656. DOI: 10.1016/j.trsl.2022.08.006. View

13.

Tian Q, Liu S, Han S, Zhang W, Qin X, Chen J . The mechanism and relevant mediators associated with neuronal apoptosis and potential therapeutic targets in subarachnoid hemorrhage. Neural Regen Res. 2022; 18(2):244-252. PMC: 9396483. DOI: 10.4103/1673-5374.346542. View

14.

Satomi J, Hadeishi H, Yoshida Y, Suzuki A, Nagahiro S . Histopathological Findings in Brains of Patients Who Died in the Acute Stage of Poor-grade Subarachnoid Hemorrhage. Neurol Med Chir (Tokyo). 2016; 56(12):766-770. PMC: 5221775. DOI: 10.2176/nmc.oa.2016-0061. View

15.

Levavasseur F, Oussous S, Zubaidan T, Kosmider O, Pendino F, Rombaut D . FOXP1 regulates oxidative stress, SIRT1 expression, and resistance to chemotherapies in acute myeloid leukemia cells. Blood Adv. 2023; 7(13):3265-3275. PMC: 10336262. DOI: 10.1182/bloodadvances.2022008585. View

16.

Chen S, Ding Y, Shi S, Tu X . Schisandrin B Inhibits NLRP3 Inflammasome Pathway and Attenuates Early Brain Injury in Rats of Subarachnoid Hemorrhage. Chin J Integr Med. 2022; 28(7):594-602. DOI: 10.1007/s11655-021-3348-z. View

17.

Chen J, Zheng Z, Lu G, Chan W, Zhang Y, Wong G . Microglia activation, classification and microglia-mediated neuroinflammatory modulators in subarachnoid hemorrhage. Neural Regen Res. 2021; 17(7):1404-1411. PMC: 8771101. DOI: 10.4103/1673-5374.330589. View

18.

Liu J, Zhao X, Qin F, Zhou J, Ding F, Zhou G . Isoliquiritigenin mitigates oxidative damage after subarachnoid hemorrhage in vivo and in vitro by regulating Nrf2-dependent Signaling Pathway via Targeting of SIRT1. Phytomedicine. 2022; 105:154262. DOI: 10.1016/j.phymed.2022.154262. View

19.

Solar P, Zamani A, Lakatosova K, Joukal M . The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments. Fluids Barriers CNS. 2022; 19(1):29. PMC: 8996682. DOI: 10.1186/s12987-022-00312-4. View

20.

Yamaguchi T, Miyamoto T, Shikata E, Yamaguchi I, Shimada K, Yagi K . Activation of the NLRP3/IL-1β/MMP-9 pathway and intracranial aneurysm rupture associated with the depletion of ERα and Sirt1 in oophorectomized rats. J Neurosurg. 2022; 138(1):191-198. DOI: 10.3171/2022.4.JNS212945. View