Concordance Between Persons with Multiple Sclerosis and Treating Physician on Medication Effects and Health Status

Overview

Journal Patient Prefer Adherence

Date 2021 May 17

PMID 33994780

Citations 2

Authors

Efrat Neter

Lea Glass-Marmor

Loren Haiien

Ariel Miller

Affiliations

Soon will be listed here.

Abstract

Background: As the number of treatment options for multiple sclerosis (MS) has expanded, alignment between physician and patient on effects of medication has emerged as important for medication persistence/discontinuation.

Objective: To evaluate physician-patient agreement levels on medication effect and health status.

Methods: Persons with MS (PwMS) (n=71) participated in a cross-sectional study collecting their satisfaction (using the Treatment Satisfaction Questionnaire for Medication), intention to dis/continue treatment and global health perception; physicians assessed response to medication and global health status.

Results: Concordance between PwMS' assessment of medication effectiveness and physician's assessment on response to medication, health status and EDSS were = 0.50, = 0.57 and = -0.58, respectively.

Conclusion: The significant concordance attests to physician-patient effective communication and may contribute to improved medication adherence.

Citing Articles

Treatment Adherence in a Large Cohort of Turkish Multiple Sclerosis Population.

Seferoglu M, Cinar B, Tekan U, Avsar F, Yigit P, Sivaci A Neurol Sci. 2025; .

PMID: 39971812 DOI: 10.1007/s10072-025-08055-4.

Unveiling the Psychological Consequences of Illness Perception in Pediatric Multiple Sclerosis: A Parent-Child Study.

Aloni R, Asher G, Ben-Ari A, Menascu S Children (Basel). 2024; 11(8).

PMID: 39201863 PMC: 11352675. DOI: 10.3390/children11080929.

Large-scale cross-sectional online survey on patient-neurologist communication, burden of disease assessment and disease monitoring in people with multiple sclerosis.

Christ M, Schuh K, Bayas A Front Neurol. 2023; 13:1093352.

PMID: 36686532 PMC: 9848394. DOI: 10.3389/fneur.2022.1093352.

References

Poulos C, Wakeford C, Kinter E, Mange B, Schenk T, Jhaveri M . Patient and physician preferences for multiple sclerosis treatments in Germany: A discrete-choice experiment study. Mult Scler J Exp Transl Clin. 2020; 6(1):2055217320910778. PMC: 7065293. DOI: 10.1177/2055217320910778. View

Lejbkowicz I, Caspi O, Miller A . Participatory medicine and patient empowerment towards personalized healthcare in multiple sclerosis. Expert Rev Neurother. 2012; 12(3):343-52. DOI: 10.1586/ern.11.161. View

Atkinson M, Sinha A, Hass S, Colman S, Kumar R, Brod M . Validation of a general measure of treatment satisfaction, the Treatment Satisfaction Questionnaire for Medication (TSQM), using a national panel study of chronic disease. Health Qual Life Outcomes. 2004; 2:12. PMC: 398419. DOI: 10.1186/1477-7525-2-12. View

Lancsar E, Louviere J . Conducting discrete choice experiments to inform healthcare decision making: a user's guide. Pharmacoeconomics. 2008; 26(8):661-77. DOI: 10.2165/00019053-200826080-00004. View

Kurtzke J . Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983; 33(11):1444-52. DOI: 10.1212/wnl.33.11.1444. View

Colligan E, Metzler A, Tiryaki E . Shared decision-making in multiple sclerosis. Mult Scler. 2016; 23(2):185-190. DOI: 10.1177/1352458516671204. View

Kremenchutzky M, Walt L . Perceptions of health status in multiple sclerosis patients and their doctors. Can J Neurol Sci. 2013; 40(2):210-8. DOI: 10.1017/s0317167100013755. View

Haase R, Kullmann J, Ziemssen T . Therapy satisfaction and adherence in patients with relapsing-remitting multiple sclerosis: the THEPA-MS survey. Ther Adv Neurol Disord. 2016; 9(4):250-63. PMC: 4916516. DOI: 10.1177/1756285616634247. View

Teter B, Agashivala N, Kavak K, Chouhfeh L, Hashmonay R, Weinstock-Guttman B . Characteristics influencing therapy switch behavior after suboptimal response to first-line treatment in patients with multiple sclerosis. Mult Scler. 2013; 20(7):830-6. DOI: 10.1177/1352458513513058. View

10.

Kantor D, Bright J, Burtchell J . Perspectives from the Patient and the Healthcare Professional in Multiple Sclerosis: Social Media and Patient Education. Neurol Ther. 2017; 7(1):23-36. PMC: 5990508. DOI: 10.1007/s40120-017-0087-3. View

11.

Yeandle D, Rieckmann P, Giovannoni G, Alexandri N, Langdon D . Patient Power Revolution in Multiple Sclerosis: Navigating the New Frontier. Neurol Ther. 2018; 7(2):179-187. PMC: 6283799. DOI: 10.1007/s40120-018-0118-8. View

12.

Kasper J, Kopke S, Muhlhauser I, Nubling M, Heesen C . Informed shared decision making about immunotherapy for patients with multiple sclerosis (ISDIMS): a randomized controlled trial. Eur J Neurol. 2008; 15(12):1345-52. DOI: 10.1111/j.1468-1331.2008.02313.x. View

13.

Rothwell P, McDowell Z, Wong C, Dorman P . Doctors and patients don't agree: cross sectional study of patients' and doctors' perceptions and assessments of disability in multiple sclerosis. BMJ. 1997; 314(7094):1580-3. PMC: 2126825. DOI: 10.1136/bmj.314.7094.1580. View

14.

Filippi M, Bar-Or A, Piehl F, Preziosa P, Solari A, Vukusic S . Multiple sclerosis. Nat Rev Dis Primers. 2018; 4(1):43. DOI: 10.1038/s41572-018-0041-4. View

15.

Zettl U, Bauer-Steinhusen U, Glaser T, Hechenbichler K, Hecker M . Comparative evaluation of patients' and physicians' satisfaction with interferon beta-1b therapy. BMC Neurol. 2016; 16(1):181. PMC: 5031257. DOI: 10.1186/s12883-016-0705-1. View

16.

Heesen C, Kleiter I, Nguyen F, Schaffler N, Kasper J, Kopke S . Risk perception in natalizumab-treated multiple sclerosis patients and their neurologists. Mult Scler. 2010; 16(12):1507-12. DOI: 10.1177/1352458510379819. View

17.

Koudriavtseva T, Onesti E, Pestalozza I, Sperduti I, Jandolo B . The importance of physician-patient relationship for improvement of adherence to long-term therapy: data of survey in a cohort of multiple sclerosis patients with mild and moderate disability. Neurol Sci. 2011; 33(3):575-84. DOI: 10.1007/s10072-011-0776-0. View

18.

Glanz B, Musallam A, Rintell D, Chitnis T, Weiner H, Healy B . Treatment satisfaction in multiple sclerosis. Int J MS Care. 2014; 16(2):68-75. PMC: 4106393. DOI: 10.7224/1537-2073.2013-021. View