Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis

Overview

Journal Circ Res

Specialty Cardiology & Vascular Diseases

Date 2021 May 17

PMID 33993729

Citations 15

Authors

Hirofumi Watanabe

Brian C Belyea

Robert L Paxton

Minghong Li

Bette J Dzamba

Douglas W DeSimone

R Ariel Gomez

Maria Luisa S Sequeira-Lopez

Affiliations

Soon will be listed here.

Abstract

[Figure: see text].

Citing Articles

Crosstalk between renin and arachidonic acid (and its metabolites).

Das U, Hacimuftuoglu A, Akpinar E, Gul M, Abd El-Aty A Lipids Health Dis. 2025; 24(1):52.

PMID: 39962508 PMC: 11831833. DOI: 10.1186/s12944-025-02463-3.

Piezo channels in JG cells do not regulate renin expression or renin release to the circulation.

Nagalakshmi V, Smith J, Matsuoka D, Gomez R, Sequeira-Lopez M Clin Sci (Lond). 2024; 138(23):1527-1536.

PMID: 39564667 PMC: 11843579. DOI: 10.1042/CS20242089.

Anoikis in cell fate, physiopathology, and therapeutic interventions.

Mei J, Jiang X, Tian H, Rong D, Song J, Wang L MedComm (2020). 2024; 5(10):e718.

PMID: 39286778 PMC: 11401975. DOI: 10.1002/mco2.718.

A Possible Link between Cell Plasticity and Renin Expression in the Collecting Duct: A Narrative Review.

Schary N, Edemir B, Todorov V Int J Mol Sci. 2024; 25(17).

PMID: 39273497 PMC: 11395489. DOI: 10.3390/ijms25179549.

Piezo ion channels: long-sought-after mechanosensors mediating hypertension and hypertensive nephropathy.

Nagase T, Nagase M Hypertens Res. 2024; 47(10):2786-2799.

PMID: 39103520 DOI: 10.1038/s41440-024-01820-6.

References

Karamat F, Oudman I, Ris-Stalpers C, Afink G, Keijser R, Clark J . Resistance artery creatine kinase mRNA and blood pressure in humans. Hypertension. 2013; 63(1):68-73. DOI: 10.1161/HYPERTENSIONAHA.113.01352. View

Gomez R, Lopez M . Who and where is the renal baroreceptor?: the connexin hypothesis. Kidney Int. 2009; 75(5):460-2. PMC: 3025775. DOI: 10.1038/ki.2008.536. View

Trepiccione F, Gerber S, Grahammer F, Lopez-Cayuqueo K, Baudrie V, Paunescu T . Renal Atp6ap2/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System. J Am Soc Nephrol. 2016; 27(11):3320-3330. PMC: 5084887. DOI: 10.1681/ASN.2015080915. View

Janota C, Calero-Cuenca F, Gomes E . The role of the cell nucleus in mechanotransduction. Curr Opin Cell Biol. 2020; 63:204-211. DOI: 10.1016/j.ceb.2020.03.001. View

Mo C, Huang L, Cui L, Lv C, Lin D, Song L . Characterization of NMB, GRP and their receptors (BRS3, NMBR and GRPR) in chickens. J Mol Endocrinol. 2017; 59(1):61-79. DOI: 10.1530/JME-17-0020. View

Xu S, Di Z, He Y, Wang R, Ma Y, Sun R . Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against Aβ toxicity via attenuating Aβ-induced endoplasmic reticulum stress. J Neuroinflammation. 2019; 16(1):35. PMC: 6373169. DOI: 10.1186/s12974-019-1429-0. View

Gomez R, Sequeira-Lopez M . Novel Functions of Renin Precursors in Homeostasis and Disease. Physiology (Bethesda). 2015; 31(1):25-33. PMC: 4698453. DOI: 10.1152/physiol.00039.2015. View

Martinez M, Medrano S, Brown R, Tufan T, Shang S, Bertoncello N . Super-enhancers maintain renin-expressing cell identity and memory to preserve multi-system homeostasis. J Clin Invest. 2018; 128(11):4787-4803. PMC: 6205391. DOI: 10.1172/JCI121361. View

Uhler C, Shivashankar G . Regulation of genome organization and gene expression by nuclear mechanotransduction. Nat Rev Mol Cell Biol. 2017; 18(12):717-727. DOI: 10.1038/nrm.2017.101. View

10.

Kirchheim H, Ehmke H, Persson P . Physiology of the renal baroreceptor mechanism of renin release and its role in congestive heart failure. Am J Cardiol. 1988; 62(8):68E-71E. DOI: 10.1016/s0002-9149(88)80015-8. View

11.

Moh M, Tian Q, Zhang T, Lee L, Shen S . The immunoglobulin-like cell adhesion molecule hepaCAM modulates cell adhesion and motility through direct interaction with the actin cytoskeleton. J Cell Physiol. 2009; 219(2):382-91. DOI: 10.1002/jcp.21685. View

12.

Zhang X, Jiang G, Cai Y, Monkley S, Critchley D, Sheetz M . Talin depletion reveals independence of initial cell spreading from integrin activation and traction. Nat Cell Biol. 2009; 10(9):1062-8. PMC: 2746969. DOI: 10.1038/ncb1765. View

13.

Jaalouk D, Lammerding J . Mechanotransduction gone awry. Nat Rev Mol Cell Biol. 2009; 10(1):63-73. PMC: 2668954. DOI: 10.1038/nrm2597. View

14.

Gesson K, Rescheneder P, Skoruppa M, von Haeseler A, Dechat T, Foisner R . A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha. Genome Res. 2016; 26(4):462-73. PMC: 4817770. DOI: 10.1101/gr.196220.115. View

15.

Gomez R, Sequeira-Lopez M . Renin cells in homeostasis, regeneration and immune defence mechanisms. Nat Rev Nephrol. 2018; 14(4):231-245. PMC: 5854538. DOI: 10.1038/nrneph.2017.186. View

16.

Ho C, Jaalouk D, Vartiainen M, Lammerding J . Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamics. Nature. 2013; 497(7450):507-11. PMC: 3666313. DOI: 10.1038/nature12105. View

17.

Chevalier R, Everett A, Gomez R . Decreased perfusion pressure modulates renin and ANG II type 1 receptor gene expression in the rat kidney. Am J Physiol. 1993; 264(4 Pt 2):R696-702. DOI: 10.1152/ajpregu.1993.264.4.R696. View

18.

Chovatiya R, Medzhitov R . Stress, inflammation, and defense of homeostasis. Mol Cell. 2014; 54(2):281-8. PMC: 4048989. DOI: 10.1016/j.molcel.2014.03.030. View

19.

Danser A, Deinum J . Renin, prorenin and the putative (pro)renin receptor. Hypertension. 2005; 46(5):1069-76. DOI: 10.1161/01.HYP.0000186329.92187.2e. View

20.

Bachmann M, Kukkurainen S, Hytonen V, Wehrle-Haller B . Cell Adhesion by Integrins. Physiol Rev. 2019; 99(4):1655-1699. DOI: 10.1152/physrev.00036.2018. View