Extension of Chronological Lifespan in Schizosaccharomyces Pombe

Overview

Journal Genes Cells

Specialties Cell Biology
Molecular Biology

Date 2021 May 12

PMID 33977597

Citations 6

Authors

Hokuto Ohtsuka

Takafumi Shimasaki

Hirofumi Aiba

Affiliations

Soon will be listed here.

Abstract

There are several examples in the nature wherein the mechanism of longevity control of unicellular organisms is evolutionarily conserved with that of higher multicellular organisms. The present microreview focuses on aging and longevity studies, particularly on chronological lifespan (CLS) concerning the unicellular eukaryotic fission yeast Schizosaccharomyces pombe. In S. pombe, >30 compounds, 8 types of nutrient restriction, and >80 genes that extend CLS have been reported. Several CLS control mechanisms are known to be involved in nutritional response, energy utilization, stress responses, translation, autophagy, and sexual differentiation. In unicellular organisms, the control of CLS is directly linked to the mechanism by which cells are maintained in limited-resource environments, and their genetic information is left to posterity. We believe that this important mechanism may have been preserved as a lifespan control mechanism for higher organisms.

Citing Articles

Structure-based engineering of Tor complexes reveals that two types of yeast TORC1 produce distinct phenotypes.

Kamada Y, Umeda C, Mukai Y, Ohtsuka H, Otsubo Y, Yamashita A J Cell Sci. 2024; 137(4).

PMID: 38415789 PMC: 10941655. DOI: 10.1242/jcs.261625.

The ecl family gene ecl3+ is induced by phosphate starvation and contributes to sexual differentiation in fission yeast.

Ohtsuka H, Sakata H, Kitazaki Y, Tada M, Shimasaki T, Otsubo Y J Cell Sci. 2023; 136(6).

PMID: 36779416 PMC: 10038150. DOI: 10.1242/jcs.260759.

Sporulation: A response to starvation in the fission yeast Schizosaccharomyces pombe.

Ohtsuka H, Imada K, Shimasaki T, Aiba H Microbiologyopen. 2022; 11(3):e1303.

PMID: 35765188 PMC: 9214231. DOI: 10.1002/mbo3.1303.

Response to leucine in Schizosaccharomyces pombe (fission yeast).

Ohtsuka H, Shimasaki T, Aiba H FEMS Yeast Res. 2022; 22(1).

PMID: 35325114 PMC: 9041340. DOI: 10.1093/femsyr/foac020.

Response to sulfur in Schizosaccharomyces pombe.

Ohtsuka H, Shimasaki T, Aiba H FEMS Yeast Res. 2021; 21(5).

PMID: 34279603 PMC: 8310684. DOI: 10.1093/femsyr/foab041.

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