Dynamic Adult Tracheal Plasticity Drives Stem Cell Adaptation to Changes in Intestinal Homeostasis in Drosophila

Overview

Journal Nat Cell Biol

Specialty Cell Biology

Date 2021 May 11

PMID 33972729

Citations 13

Authors

Jessica Perochon

Yachuan Yu

Gabriel N Aughey

Andre B Medina

Tony D Southall

Julia B Cordero

Affiliations

Soon will be listed here.

Abstract

Coordination of stem cell function by local and niche-derived signals is essential to preserve adult tissue homeostasis and organismal health. The vasculature is a prominent component of multiple stem cell niches. However, its role in adult intestinal homeostasis remains largely understudied. Here we uncover a previously unrecognised crosstalk between adult intestinal stem cells in Drosophila and the vasculature-like tracheal system, which is essential for intestinal regeneration. Following damage to the intestinal epithelium, gut-derived reactive oxygen species activate tracheal HIF-1α and bidirectional FGF/FGFR signalling, leading to reversible remodelling of gut-associated terminal tracheal cells and intestinal stem cell proliferation following damage. Unexpectedly, reactive oxygen species-induced adult tracheal plasticity involves downregulation of the tracheal specification factor trachealess (trh) and upregulation of IGF2 messenger RNA-binding protein (IGF2BP2/Imp). Our results reveal an intestine-vasculature inter-organ communication programme that is essential to adapt the stem cell response to the proliferative demands of the intestinal epithelium.

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