Integrative Transcriptomic Analysis of Tissue-specific Metabolic Crosstalk After Myocardial Infarction

Overview

Journal Elife

Specialty Biology

Date 2021 May 11

PMID 33972017

Citations 23

Authors

Muhammad Arif

Martina Klevstig

Rui Benfeitas

Stephen Doran

Hasan Turkez

Mathias Uhlen

Maryam Clausen

Johannes Wikstrom

Damla Etal

Cheng Zhang

Malin Levin

Adil Mardinoglu

Jan Boren

Affiliations

Soon will be listed here.

Abstract

Myocardial infarction (MI) promotes a range of systemic effects, many of which are unknown. Here, we investigated the alterations associated with MI progression in heart and other metabolically active tissues (liver, skeletal muscle, and adipose) in a mouse model of MI (induced by ligating the left ascending coronary artery) and sham-operated mice. We performed a genome-wide transcriptomic analysis on tissue samples obtained 6- and 24 hr post MI or sham operation. By generating tissue-specific biological networks, we observed: (1) dysregulation in multiple biological processes (including immune system, mitochondrial dysfunction, fatty-acid beta-oxidation, and RNA and protein processing) across multiple tissues post MI and (2) tissue-specific dysregulation in biological processes in liver and heart post MI. Finally, we validated our findings in two independent MI cohorts. Overall, our integrative analysis highlighted both common and specific biological responses to MI across a range of metabolically active tissues.

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