Gastrointestinal Cytomegalovirus Disease Secondary to Measles in an Immunocompetent Infant: A Case Report

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2021 May 7

PMID 33958850

Citations 1

Authors

Qing-Hua Yang

Xiao-Peng Ma

Dong-Ling Dai

Da-Ming Bai

Yu Zou

Si-Xi Liu

Jian-Ming Song

Affiliations

Soon will be listed here.

Abstract

Background: Gastrointestinal cytomegalovirus (CMV) disease occurs commonly in immunocompromised/immunodeficient patients with advanced human immunodeficiency virus infection, neoplasm, solid organ transplantation, hematopoietic stem cell transplantation, or treatment with immunosuppressants, but is rarely reported in association with measles infection.

Case Summary: We describe a case of extensive gastrointestinal CMV disease secondary to measles infection in a 9-mo-old boy who presented with persistent fever and bloody diarrhea. His condition was improved after ganciclovir treatment. Serological analysis of CMV showed negative immunoglobulin (Ig) M and positive IgG. Blood CMV-DNA was 9.26 × 10 copies/mL. The diagnosis of gastrointestinal CMV disease was confirmed by histopathological findings of intranuclear and intracytoplasmic inclusions and Owl's eye inclusion. This case highlights the differential diagnosis and histopathological characteristics of gastrointestinal CMV infection and laboratory tests.

Conclusion: Extensive gastrointestinal CMV lesions can be induced by the immune suppression secondary to measles infection. Rational, fast, and effective laboratory examinations are essential for suspected patients.

Citing Articles

Gastrointestinal cytomegalovirus disease secondary to measles in an immunocompetent infant.

Hung C, Lee P, Lee H, Chiu C World J Gastroenterol. 2021; 27(25):3948-3950.

PMID: 34321857 PMC: 8291027. DOI: 10.3748/wjg.v27.i25.3948.

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