A Meta-analysis of Gut Microbiota in Children with Autism

Overview

Journal J Autism Dev Disord

Publisher Springer

Date 2021 May 5

PMID 33948825

Citations 35

Authors

Pedro Andreo-Martinez

Maria Rubio-Aparicio

Julio Sanchez-Meca

Alejandro Veas

Agustin Ernesto Martinez-Gonzalez

Affiliations

Soon will be listed here.

Abstract

Previous studies have reported dysbiosis in the gut microbiota (GM) of children with autism spectrum disorders (ASD), which may be a determining factor on child development through the microbiota-gut-brain axis. However, it is not clear if there is a specific group of dysbiotic bacteria in ASD. The aim of this study was to carry out a meta-analysis on the studies that analyze GM in children with ASD. 18 studies fulfilled our selection criteria. Our results showed a lower relative abundance of Streptococcus (SMD = - 0.999; 95% CI - 1.549, - 0.449) and Bifidobacterium genera (SMD = - 0.513; 95% CI - 0.953, - 0.073) in children with ASD. Overall, the Bifidobacterium genera is involved. However, differences found between studies are attributed to factors such as reporting bias.

Citing Articles

Cross-cultural differences in autistic characteristics: a comparison between Spain and Colombia.

Martinez-Gonzalez A, Rodriguez-Jimenez T, Riano-Hernandez D, Alexandra-Atehortua P, Ramirez-Conde A, Ramirez-Garcia L Int J Dev Disabil. 2025; 71(1):105-114.

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Development and Psychometric Properties of the Pain and Sensitivity Reactivity Scale in a Diverse Sample of Autistic People.

Martinez-Gonzalez A, Cervin M, Piqueras J, Infante-Canete L, Perez-Sanchez S Children (Basel). 2025; 11(12.

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Wang J, Yang R, Zhong H, Liu Y World J Pediatr. 2024; 20(12):1201-1204.

PMID: 39548040 DOI: 10.1007/s12519-024-00855-6.

Correction of Batch Effect in Gut Microbiota Profiling of ASD Cohorts from Different Geographical Origins.

Scanu M, Del Chierico F, Marsiglia R, Toto F, Guerrera S, Valeri G Biomedicines. 2024; 12(10).

PMID: 39457661 PMC: 11504477. DOI: 10.3390/biomedicines12102350.

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