Review of Microbiota Gut Brain Axis and Innate Immunity in Inflammatory and Infective Diseases

Overview

Journal Front Cell Infect Microbiol

Specialties Cell Biology
Infectious Diseases
Microbiology

Date 2023 Oct 23

PMID 37868345

Authors

Chongshan Yuan

Yuhong He

Kunyu Xie

Lianjun Feng

Shouyang Gao

Lifu Cai

Affiliations

Soon will be listed here.

Abstract

The microbiota gut brain (MGB) axis has been shown to play a significant role in the regulation of inflammatory and infective diseases. Exploring the structure and communication mode of MGB axis is crucial for understanding its role in diseases, and studying the signaling pathways and regulatory methods of MGB axis regulation in diseases is also of profound significance for future clinical research. This article reviews the composition, communication mechanism of MGB axis and its role in inflammatory and infective diseases, including Parkinson's disease (PD), Alzheimer's disease (AD), multiple sclerosis (MS), autism spectrum disorder (ASD), depression, psoriasis, irritable bowel syndrome (IBS), and inflammatory bowel diseases (IBD). In addition, our investigation delved into the regulatory functions of the inflammasome, IFN-I, NF-κB, and PARK7/DJ-1 innate immune signaling pathway in the context of inflammatory and infective diseases. Ultimately, we discussed the efficacy of various interventions, including fecal microbiota transplantation (FMT), antibiotics, probiotics, prebiotics, synbiotics, and postbiotics, in the management of inflammatory and infective diseases. Understanding the role and mechanism of the MGB axis might make positive effects in the treatment of inflammatory and infective diseases.

Citing Articles

Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer's Disease.

Gualtieri P, Frank G, Cianci R, Ciancarella L, Romano L, Ortoman M Nutrients. 2025; 17(5).

PMID: 40077790 PMC: 11901643. DOI: 10.3390/nu17050922.

infection and its impact on psoriasis: a systematic review and meta-analysis.

Yan Y, Deng W, Shi C, Xie J, Sui D Front Med (Lausanne). 2024; 11:1500670.

PMID: 39712183 PMC: 11659017. DOI: 10.3389/fmed.2024.1500670.

Current Strategies and Future Directions of Wearable Biosensors for Measuring Stress Biochemical Markers for Neuropsychiatric Applications.

Sheffield Z, Paul P, Krishnakumar S, Pan D Adv Sci (Weinh). 2024; 12(5):e2411339.

PMID: 39688117 PMC: 11791988. DOI: 10.1002/advs.202411339.

Gut microbiota and psoriasis: pathogenesis, targeted therapy, and future directions.

Zou X, Zou X, Gao L, Zhao H Front Cell Infect Microbiol. 2024; 14:1430586.

PMID: 39170985 PMC: 11335719. DOI: 10.3389/fcimb.2024.1430586.

Gut-Brain Axis: Focus on Sex Differences in Neuroinflammation.

Caldarelli M, Rio P, Marrone A, Ocarino F, Chiantore M, Candelli M Int J Mol Sci. 2024; 25(10).

PMID: 38791415 PMC: 11120930. DOI: 10.3390/ijms25105377.

References

Logsdon A, Erickson M, Rhea E, Salameh T, Banks W . Gut reactions: How the blood-brain barrier connects the microbiome and the brain. Exp Biol Med (Maywood). 2017; 243(2):159-165. PMC: 5788145. DOI: 10.1177/1535370217743766. View

Vogt N, Kerby R, Dill-McFarland K, Harding S, Merluzzi A, Johnson S . Gut microbiome alterations in Alzheimer's disease. Sci Rep. 2017; 7(1):13537. PMC: 5648830. DOI: 10.1038/s41598-017-13601-y. View

Zheng M, Karki R, Williams E, Yang D, Fitzpatrick E, Vogel P . TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines. Nat Immunol. 2021; 22(7):829-838. PMC: 8882317. DOI: 10.1038/s41590-021-00937-x. View

Liu Y, Sanderson D, Mian M, McVey Neufeld K, Forsythe P . Loss of vagal integrity disrupts immune components of the microbiota-gut-brain axis and inhibits the effect of Lactobacillus rhamnosus on behavior and the corticosterone stress response. Neuropharmacology. 2021; 195:108682. DOI: 10.1016/j.neuropharm.2021.108682. View

Jang H, Lee K, Kim D . The Preventive and Curative Effects of Lactobacillus reuteri NK33 and Bifidobacterium adolescentis NK98 on Immobilization Stress-Induced Anxiety/Depression and Colitis in Mice. Nutrients. 2019; 11(4). PMC: 6521032. DOI: 10.3390/nu11040819. View

Li H, Zhou D, Gan R, Huang S, Zhao C, Shang A . Effects and Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics on Metabolic Diseases Targeting Gut Microbiota: A Narrative Review. Nutrients. 2021; 13(9). PMC: 8470858. DOI: 10.3390/nu13093211. View

Chan K, Cathomas F, Russo S . Central and Peripheral Inflammation Link Metabolic Syndrome and Major Depressive Disorder. Physiology (Bethesda). 2019; 34(2):123-133. PMC: 6586832. DOI: 10.1152/physiol.00047.2018. View

Taylor J, Moore Z, Minter M, Crack P . Type-I interferon pathway in neuroinflammation and neurodegeneration: focus on Alzheimer's disease. J Neural Transm (Vienna). 2017; 125(5):797-807. DOI: 10.1007/s00702-017-1745-4. View

Berer K, Gerdes L, Cekanaviciute E, Jia X, Xiao L, Xia Z . Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A. 2017; 114(40):10719-10724. PMC: 5635914. DOI: 10.1073/pnas.1711233114. View

10.

Mossad O, Blank T . Getting on in Old Age: How the Gut Microbiota Interferes With Brain Innate Immunity. Front Cell Neurosci. 2021; 15:698126. PMC: 8290125. DOI: 10.3389/fncel.2021.698126. View

11.

Kazemi A, Noorbala A, Azam K, Eskandari M, Djafarian K . Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial. Clin Nutr. 2018; 38(2):522-528. DOI: 10.1016/j.clnu.2018.04.010. View

12.

Sharma A, Batra G, Saini L, Sharma S, Mishra A, Singla R . Valproic Acid and Propionic Acid Modulated Mechanical Pathways Associated with Autism Spectrum Disorder at Prenatal and Neonatal Exposure. CNS Neurol Disord Drug Targets. 2021; 21(5):399-408. DOI: 10.2174/1871527320666210806165430. View

13.

Pittayanon R, Lau J, Yuan Y, Leontiadis G, Tse F, Surette M . Gut Microbiota in Patients With Irritable Bowel Syndrome-A Systematic Review. Gastroenterology. 2019; 157(1):97-108. DOI: 10.1053/j.gastro.2019.03.049. View

14.

Dinan T, Cryan J . The Microbiome-Gut-Brain Axis in Health and Disease. Gastroenterol Clin North Am. 2017; 46(1):77-89. DOI: 10.1016/j.gtc.2016.09.007. View

15.

Kaufmann M, Evans H, Schaupp A, Engler J, Kaur G, Willing A . Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis. Med. 2021; 2(3):296-312.e8. PMC: 7966680. DOI: 10.1016/j.medj.2021.01.006. View

16.

Tankou S, Regev K, Healy B, Cox L, Tjon E, Kivisakk P . Investigation of probiotics in multiple sclerosis. Mult Scler. 2018; 24(1):58-63. DOI: 10.1177/1352458517737390. View

17.

Balmus I, Ciobica A, Cojocariu R, Luca A, Gorgan L . Irritable Bowel Syndrome and Neurological Deficiencies: Is There A Relationship? The Possible Relevance of the Oxidative Stress Status. Medicina (Kaunas). 2020; 56(4). PMC: 7230401. DOI: 10.3390/medicina56040175. View

18.

Sumida T, Dulberg S, Schupp J, Lincoln M, Stillwell H, Axisa P . Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells. Nat Immunol. 2022; 23(4):632-642. PMC: 8989655. DOI: 10.1038/s41590-022-01152-y. View

19.

Sun M, Zhu Y, Zhou Z, Jia X, Xu Y, Yang Q . Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice: Gut microbiota, glial reaction and TLR4/TNF-α signaling pathway. Brain Behav Immun. 2018; 70:48-60. DOI: 10.1016/j.bbi.2018.02.005. View

20.

Brummelte S, Mc Glanaghy E, Bonnin A, Oberlander T . Developmental changes in serotonin signaling: Implications for early brain function, behavior and adaptation. Neuroscience. 2016; 342:212-231. PMC: 5310545. DOI: 10.1016/j.neuroscience.2016.02.037. View