Molecular Functions of WWOX Potentially Involved in Cancer Development

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2021 May 5

PMID 33946771

Citations 13

Authors

Karim Taouis

Keltouma Driouch

Rosette Lidereau

Francois Lallemand

Affiliations

Soon will be listed here.

Abstract

The WW domain-containing oxidoreductase gene () was cloned 21 years ago as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The localization of in a chromosomal region frequently altered in human cancers has initiated multiple current studies to establish its role in this disease. All of this work suggests that WWOX, due to its ability to interact with a large number of partners, exerts its tumor suppressive activity through a wide variety of molecular actions that are mostly cell specific.

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