Biological Functions of IL-17-producing Cells in Mycoplasma Respiratory Infection

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 2021 Apr 30

PMID 33930194

Citations 9

Authors

Ying Luo

Cheng Li

Zhou Zhou

Zhande Gong

Cuiming Zhu

Aihua Lei

Affiliations

Soon will be listed here.

Abstract

Mycoplasmas are the smallest and simplest bacteria that lack a cell wall but have the capability of self-replication. Among them, Mycoplasma pneumoniae is one of the most common causes of community-acquired pneumonia. The hallmark of mycoplasma respiratory diseases is the persistence of lung inflammation that involves both innate and adaptive immune responses. In recent years, a growing body of evidence demonstrates that IL-17 plays an important role in respiratory mycoplasma infection, and associates with the pathologic outcomes of infection, such as pneumonitis and asthma. Numerous studies have shown that a variety of cells, in particular Th17 cells, in the lung can secrete IL-17 during respiratory mycoplasma infection. In this article, we review the biological functions of distinct IL-17-producing cells in mycoplasma respiratory infection with a focus on the effect of IL-17 on the outcomes of infection.

Citing Articles

An immunohistochemical study on the evaluation of mast cell, interleukin 17 and interleukin 1β profile in contagious caprine pleuropneumonia.

Karatas O, Akcakavak G Vet Res Forum. 2024; 15(10):515-521.

PMID: 39588464 PMC: 11585848. DOI: 10.30466/vrf.2024.2023580.4184.

Serum Levels of Selected Cytokines and Chemokines and IgG4 in Children With Recurrent Respiratory Tract Infections.

Machura E, Krakowczyk H, Kleszyk M, Swietochowska E, Grzywna-Rozenek E, Rusek M J Immunol Res. 2024; 2024:5170588.

PMID: 39431236 PMC: 11490343. DOI: 10.1155/2024/5170588.

Association of serum interleukin-17 level and pneumonia in children: a systematic review and meta-analysis.

Leerach N, Sitthisak S, Kitti T, Teerawattanapong N, Mahikul W, Lamlertthon S Transl Pediatr. 2024; 13(9):1588-1599.

PMID: 39399709 PMC: 11467231. DOI: 10.21037/tp-24-218.

Integrative study of pulmonary microbiome, transcriptome and clinical outcomes in Mycoplasma pneumoniae pneumonia.

Huang X, Luo Y, Wang J, Zhang X, Chen L, Wu R Respir Res. 2024; 25(1):35.

PMID: 38238712 PMC: 10795342. DOI: 10.1186/s12931-024-02687-4.

Chimeric proteins of Mycoplasma hyopneumoniae as vaccine and preclinical model for immunological evaluation.

Santos M, Toledo L, Bassi E, Porto W, Bressan G, Moreira M Braz J Microbiol. 2024; 55(1):943-953.

PMID: 38217795 PMC: 10920614. DOI: 10.1007/s42770-023-01240-7.

References

Jones H, Tabor L, Sun X, Woolard M, Simecka J . Depletion of CD8+ T cells exacerbates CD4+ Th cell-associated inflammatory lesions during murine mycoplasma respiratory disease. J Immunol. 2002; 168(7):3493-501. DOI: 10.4049/jimmunol.168.7.3493. View

Kim B, Lee J, Ko Y . Mycoplasma exploits mammalian tunneling nanotubes for cell-to-cell dissemination. BMB Rep. 2019; 52(8):490-495. PMC: 6726209. View

Lu B, Liu M, Wang J, Fan H, Yang D, Zhang L . IL-17 production by tissue-resident MAIT cells is locally induced in children with pneumonia. Mucosal Immunol. 2020; 13(5):824-835. PMC: 7434594. DOI: 10.1038/s41385-020-0273-y. View

Dai W, Wang H, Zhou Q, Feng X, Lu Z, Li D . The concordance between upper and lower respiratory microbiota in children with Mycoplasma pneumoniae pneumonia. Emerg Microbes Infect. 2018; 7(1):92. PMC: 5964150. DOI: 10.1038/s41426-018-0097-y. View

Chao J, Han X, Liu K, Li Q, Peng Q, Lu S . Calves Infected with Virulent and Attenuated Strains Have Upregulated Th17 Inflammatory and Th1 Protective Responses, Respectively. Genes (Basel). 2019; 10(9). PMC: 6770603. DOI: 10.3390/genes10090656. View

Jimbo S, Suleman M, Maina T, Prysliak T, Mulongo M, Perez-Casal J . Effect of Mycoplasma bovis on bovine neutrophils. Vet Immunol Immunopathol. 2017; 188:27-33. DOI: 10.1016/j.vetimm.2017.04.011. View

Paats M, Bergen I, Hanselaar W, van Zoelen E, Verbrugh H, Hoogsteden H . T helper 17 cells are involved in the local and systemic inflammatory response in community-acquired pneumonia. Thorax. 2013; 68(5):468-74. DOI: 10.1136/thoraxjnl-2012-202168. View

Smith C, Golden C, Kanner R, RENZETTI Jr A . Association of viral and Mycoplasma pneumoniae infections with acute respiratory illness in patients with chronic obstructive pulmonary diseases. Am Rev Respir Dis. 1980; 121(2):225-32. DOI: 10.1164/arrd.1980.121.2.225. View

Dobbs N, Odeh A, Sun X, Simecka J . THE MULTIFACETED ROLE OF T CELL-MEDIATED IMMUNITY IN PATHOGENESIS AND RESISTANCE TO MYCOPLASMA RESPIRATORY DISEASE. Curr Trends Immunol. 2011; 10:1-19. PMC: 3131222. View

10.

Mai J, Wang H, Yang X . Th 17 cells interplay with Foxp3+ Tregs in regulation of inflammation and autoimmunity. Front Biosci (Landmark Ed). 2010; 15(3):986-1006. PMC: 2880832. DOI: 10.2741/3657. View

11.

Wang H, Zhou Q, Dai W, Feng X, Lu Z, Yang Z . Lung Microbiota and Pulmonary Inflammatory Cytokines Expression Vary in Children With Tracheomalacia and Adenoviral or Pneumonia. Front Pediatr. 2019; 7:265. PMC: 6611399. DOI: 10.3389/fped.2019.00265. View

12.

Ciric B, El-Behi M, Cabrera R, Zhang G, Rostami A . IL-23 drives pathogenic IL-17-producing CD8+ T cells. J Immunol. 2009; 182(9):5296-305. DOI: 10.4049/jimmunol.0900036. View

13.

Sterner-Kock A, Haider W, Sacchini F, Liljander A, Meens J, Poole J . Morphological characterization and immunohistochemical detection of the proinflammatory cytokines IL-1β, IL-17A, and TNF-α in lung lesions associated with contagious bovine pleuropneumonia. Trop Anim Health Prod. 2016; 48(3):569-76. PMC: 4766205. DOI: 10.1007/s11250-016-0994-9. View

14.

Raymond B, Turnbull L, Jenkins C, Madhkoor R, Schleicher I, Uphoff C . Mycoplasma hyopneumoniae resides intracellularly within porcine epithelial cells. Sci Rep. 2018; 8(1):17697. PMC: 6283846. DOI: 10.1038/s41598-018-36054-3. View

15.

Wang H, Kjer-Nielsen L, Shi M, DSouza C, Pediongco T, Cao H . IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection. Sci Immunol. 2019; 4(41). DOI: 10.1126/sciimmunol.aaw0402. View

16.

Messous S, Trabelsi I, Grissa M, Nouira S, Pozzetto B, Mastouri M . Prevalence of Chlamydophila pneumoniae and Mycoplasma pneumoniae IgM and IgG antibodies in Tunisian patients presenting with exacerbation of chronic obstructive pulmonary disease. Med Mal Infect. 2017; 47(2):158-163. DOI: 10.1016/j.medmal.2016.12.002. View

17.

Park H, Li Z, Yang X, Chang S, Nurieva R, Wang Y . A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005; 6(11):1133-41. PMC: 1618871. DOI: 10.1038/ni1261. View

18.

Mize M, Sun X, Simecka J . Interleukin-17A Exacerbates Disease Severity in BALB/c Mice Susceptible to Lung Infection with Mycoplasma pulmonis. Infect Immun. 2018; 86(9). PMC: 6105906. DOI: 10.1128/IAI.00292-18. View

19.

Odeh A, Simecka J . Regulatory CD4+CD25+ T Cells Dampen Inflammatory Disease in Murine Mycoplasma Pneumonia and Promote IL-17 and IFN-γ Responses. PLoS One. 2016; 11(5):e0155648. PMC: 4866680. DOI: 10.1371/journal.pone.0155648. View

20.

Cassell G . Derrick Edward Award Lecture. The pathogenic potential of mycoplasmas: Mycoplasma pulmonis as a model. Rev Infect Dis. 1982; 4 Suppl:S18-34. DOI: 10.1093/clinids/4.supplement_1.s18. View