Circular RNAs and Cardiovascular Regeneration

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2021 Apr 30

PMID 33928139

Citations 7

Authors

Ling Tang

Pengsheng Li

Michelle Jang

Wuqiang Zhu

Affiliations

Soon will be listed here.

Abstract

circular RNAs (circRNAs) are a type of non-coding RNAs that are widely present in eukaryotic cells. They have the characteristics of stable structure, high abundance, and cell or tissue specific expression. circRNAs are single-stranded RNAs that are covalently back spliced to form closed circular loops. They may participate in gene expression and regulation through a variety of action modes. circRNAs can encode proteins or function by acting as miRNA sponges for protein translation. Since 2016, a growing number of research studies have shown that circRNAs play important role in the pathogenesis of cardiovascular disease. With the construction of circRNA database, the differential expression of circRNAs in the heart tissue samples from different species and the gradual elucidation of its mode of action in disease may become an ideal diagnosis biomarker and an effective therapeutic target. What can be expected surely has a broader application prospect. In this review, we summarize recent publications on circRNA biogenesis, expression profiles, functions, and the most recent studies of circRNAs in the field of cardiovascular diseases with special emphasis on cardiac regeneration.

Citing Articles

Three-layer heterogeneous network based on the integration of CircRNA information for MiRNA-disease association prediction.

Qu J, Liu S, Li H, Zhou J, Bian Z, Song Z PeerJ Comput Sci. 2024; 10:e2070.

PMID: 38983241 PMC: 11232581. DOI: 10.7717/peerj-cs.2070.

Identification of circular RNAs regulating cardiomyocyte proliferation in neonatal pig hearts.

Tang L, Nyarige V, Li P, Wang J, Zhu W JCI Insight. 2024; 9(15).

PMID: 38916964 PMC: 11383601. DOI: 10.1172/jci.insight.175625.

Non-Coding Ribonucleic Acids as Diagnostic and Therapeutic Targets in Cardiac Fibrosis.

Olson S, Tang W, Liu C Curr Heart Fail Rep. 2024; 21(3):262-275.

PMID: 38485860 PMC: 11090942. DOI: 10.1007/s11897-024-00653-1.

Clinical Significance of MicroRNAs, Long Non-Coding RNAs, and CircRNAs in Cardiovascular Diseases.

Singh D, Kim Y, Choi S, Han I, Yadav D Cells. 2023; 12(12).

PMID: 37371099 PMC: 10297435. DOI: 10.3390/cells12121629.

The Landscape of Circular RNAs in Cardiovascular Diseases.

Long Q, Lv B, Jiang S, Lin J Int J Mol Sci. 2023; 24(5).

PMID: 36902000 PMC: 10003248. DOI: 10.3390/ijms24054571.

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