Regulation of Intestinal Inflammation by Soybean and Soy-Derived Compounds

Overview

Journal Foods

Specialty Biotechnology

Date 2021 Apr 30

PMID 33916612

Citations 14

Authors

Abigail Raffner Basson

Saleh Ahmed

Rawan Almutairi

Brian Seo

Fabio Cominelli

Affiliations

Soon will be listed here.

Abstract

Environmental factors, particularly diet, are considered central to the pathogenesis of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. In particular, the Westernization of diet, characterized by high intake of animal protein, saturated fat, and refined carbohydrates, has been shown to contribute to the development and progression of IBD. During the last decade, soybean, as well as soy-derived bioactive compounds (e.g., isoflavones, phytosterols, Bowman-Birk inhibitors) have been increasingly investigated because of their anti-inflammatory properties in animal models of IBD. Herein we provide a scoping review of the most studied disease mechanisms associated with disease induction and progression in IBD rodent models after feeding of either the whole food or a bioactive present in soybean.

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