Vitamin D Levels in Children with Attention Deficit Hyperactivity Disorder: Association with Seasonal and Geographical Variation, Supplementation, Inattention Severity, and Theta:beta Ratio

Overview

Journal Biol Psychol

Specialty Psychiatry

Date 2021 Apr 29

PMID 33915215

Citations 2

Authors

Melissa C Miller

Xueliang Pan

L Eugene Arnold

Arielle Mulligan

Shea Connor

Rachel Bergman

Roger deBeus

Michelle E Roley-Roberts

Affiliations

Soon will be listed here.

Abstract

We examined seasonal and geographic effects on vitamin D [25(OH)D] levels, association with attention-deficit/hyperactivity disorder (ADHD) symptom severity, and effects of supplementation in 222 children age 7-10 with rigorously diagnosed ADHD. 25(OH)D insufficiency rates were 47.2 % in Ohio and 28.5 % 400 miles south in North Carolina. Nadir of 25(OH)D levels was reached by November in Ohio, not until January in NC. Thirty-eight children with insufficiency/deficiency took vitamin D (1000-2000 IU/day for a month); levels rose 52 %. Although inattention did not correlate with 25(OH)D at screen nor improve significantly with supplementation, inattention improvement after supplementation correlated with 25(OH)D increase (rho = 0.41, p = 0.012). A clinically significant proportion of children with ADHD have insufficient 25(OH)D even at summer's end, more so in the winter and north of the 37th parallel. The significant correlation of inattention improvement with 25(OH)D increase suggests further research on 25(OH)D as ADHD treatment.

Citing Articles

Co-Occurrence of Tic Disorders and Attention-Deficit/Hyperactivity Disorder-Does It Reflect a Common Neurobiological Background?.

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Cui X, Eyles D Nutrients. 2022; 14(20).

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References

Grant W . The geographic variation in the prevalence of attention-deficit/hyperactivity disorder in the United States is likely due to geographic variations of solar ultraviolet B doses and race. Biol Psychiatry. 2013; 75(3):e1. DOI: 10.1016/j.biopsych.2013.04.031. View

Hoebert M, van der Heijden K, van Geijlswijk I, Smits M . Long-term follow-up of melatonin treatment in children with ADHD and chronic sleep onset insomnia. J Pineal Res. 2009; 47(1):1-7. DOI: 10.1111/j.1600-079X.2009.00681.x. View

Arns M, Feddema I, Kenemans J . Differential effects of theta/beta and SMR neurofeedback in ADHD on sleep onset latency. Front Hum Neurosci. 2015; 8:1019. PMC: 4274876. DOI: 10.3389/fnhum.2014.01019. View

Cortese S, Faraone S, Konofal E, Lecendreux M . Sleep in children with attention-deficit/hyperactivity disorder: meta-analysis of subjective and objective studies. J Am Acad Child Adolesc Psychiatry. 2009; 48(9):894-908. DOI: 10.1097/CHI.0b013e3181ac09c9. View

van Veen M, Kooij J, Boonstra A, Gordijn M, van Someren E . Delayed circadian rhythm in adults with attention-deficit/hyperactivity disorder and chronic sleep-onset insomnia. Biol Psychiatry. 2010; 67(11):1091-6. DOI: 10.1016/j.biopsych.2009.12.032. View

Arns M, van der Heijden K, Eugene Arnold L, Kenemans J . Reply to: The geographic variation in the prevalence of attention-deficit/hyperactivity disorder the United States is likely due to geographical variations of solar ultraviolet B doses and race. Biol Psychiatry. 2013; 75(3):e3-4. DOI: 10.1016/j.biopsych.2013.05.033. View

Holick M . Vitamin D deficiency. N Engl J Med. 2007; 357(3):266-81. DOI: 10.1056/NEJMra070553. View

Arns M, Keith Conners C, Kraemer H . A decade of EEG Theta/Beta Ratio Research in ADHD: a meta-analysis. J Atten Disord. 2012; 17(5):374-83. DOI: 10.1177/1087054712460087. View

Conners C, Sitarenios G, Parker J, Epstein J . The revised Conners' Parent Rating Scale (CPRS-R): factor structure, reliability, and criterion validity. J Abnorm Child Psychol. 1998; 26(4):257-68. DOI: 10.1023/a:1022602400621. View

10.

Webb A, Kline L, Holick M . Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab. 1988; 67(2):373-8. DOI: 10.1210/jcem-67-2-373. View

11.

Langberg J, Molina B, Eugene Arnold L, Epstein J, Altaye M, Hinshaw S . Patterns and predictors of adolescent academic achievement and performance in a sample of children with attention-deficit/hyperactivity disorder. J Clin Child Adolesc Psychol. 2011; 40(4):519-31. PMC: 3132152. DOI: 10.1080/15374416.2011.581620. View

12.

van der Heijden K, Smits M, van Someren E, Gunning W . Idiopathic chronic sleep onset insomnia in attention-deficit/hyperactivity disorder: a circadian rhythm sleep disorder. Chronobiol Int. 2005; 22(3):559-70. DOI: 10.1081/CBI-200062410. View

13.

Thapar A . Discoveries on the Genetics of ADHD in the 21st Century: New Findings and Their Implications. Am J Psychiatry. 2018; 175(10):943-950. DOI: 10.1176/appi.ajp.2018.18040383. View

14.

Autier P, Boniol M, Pizot C, Mullie P . Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol. 2014; 2(1):76-89. DOI: 10.1016/S2213-8587(13)70165-7. View

15.

van der Heijden K, Smits M, van Someren E, Gunning W . Prediction of melatonin efficacy by pretreatment dim light melatonin onset in children with idiopathic chronic sleep onset insomnia. J Sleep Res. 2005; 14(2):187-94. DOI: 10.1111/j.1365-2869.2005.00451.x. View

16.

Daley D, Birchwood J . ADHD and academic performance: why does ADHD impact on academic performance and what can be done to support ADHD children in the classroom?. Child Care Health Dev. 2010; 36(4):455-64. DOI: 10.1111/j.1365-2214.2009.01046.x. View

17.

Holick M . High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006; 81(3):353-73. DOI: 10.4065/81.3.353. View

18.

Khoshbakht Y, Bidaki R, Salehi-Abargouei A . Vitamin D Status and Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-Analysis of Observational Studies. Adv Nutr. 2018; 9(1):9-20. PMC: 6333940. DOI: 10.1093/advances/nmx002. View

19.

Moore C, Murphy M, Keast D, Holick M . Vitamin D intake in the United States. J Am Diet Assoc. 2004; 104(6):980-3. DOI: 10.1016/j.jada.2004.03.028. View

20.

Schoenfelder E, Kollins S . Topical Review: ADHD and Health-Risk Behaviors: Toward Prevention and Health Promotion. J Pediatr Psychol. 2016; 41(7):735-40. PMC: 6281045. DOI: 10.1093/jpepsy/jsv162. View