Longitudinal Study of Experimentally Induced Periodontal Disease in Macaca Arctoides: Relationship Between Microflora and Alveolar Bone Loss

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1979 Feb 1

PMID 33902

Citations 18

Authors

J Slots

E Hausmann

Affiliations

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Abstract

Macaca arctoides monkeys develop periodontal disease, and they harbor a periodontopathic indigenous flora largely similar to that of humans. This study showed that various Haemophilus isolates and H2O2-splitting asaccharolytic Bacteroides melaninogenicus strains constituted major segments of the monkey periodontal microflora. These organisms have not been previously identified among human isolates. Furthermore, the present data revealed that asaccharolytic B. melaninogenicus strains increased in proportion from a few percent to about 66% of the total isolates concomitant with the development of a significant loss of alveolar bone mass. Hence, this study strongly implicates B. melaninogenicus subsp. asaccharolyticus and closely related strains as important pathogens in actively destructive periodontal disease.

Citing Articles

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Lymphoproliferative responses to oral bacteria in humans with varying severities of periodontal disease.

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Characteristics of Bacteroides asaccharolyticus from dental plaques of beagle dogs.

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Serum antibodies to oral Bacteroides asaccharolyticus (Bacteroides gingivalis): relationship to age and periondontal disease.

Mouton C, Hammond P, Slots J, Genco R Infect Immun. 1981; 31(1):182-92.

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Antigenic studies of oral and nonoral black-pigmented Bacteroides strains.

Reed M, Slots J, Mouton C, Genco R Infect Immun. 1980; 29(2):564-74.

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