Importance of Clonal Hematopoiesis in Heart Failure

Overview

Journal Trends Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2021 Apr 23

PMID 33892102

Citations 5

Authors

Nicholas W Chavkin

Kyung-Duk Min

Kenneth Walsh

Affiliations

Soon will be listed here.

Abstract

Heart failure is prevalent in the elderly population. Inflammatory processes can contribute to the progression of heart failure by altering the balance of tissue healing and pathological remodeling during the injury response. New findings show that aging can alter immune cell phenotypes through the process of clonal hematopoiesis. This condition results from acquired somatic DNA mutations in specific driver genes that give rise to clonal expansions of mutant hematopoietic cells with overactive inflammatory properties. Recent clinical and experimental studies have shown that clonal hematopoiesis is prevalent in heart failure patients and associated with poor prognosis. In this review, we summarize current evidence that associates clonal hematopoiesis with the progression of heart failure. We further describe the mechanistic links between clonal hematopoiesis and the pro-inflammatory responses that can contribute to pathological outcomes in the heart. Finally, we provide perspectives on future research directions in the area of clonal hematopoiesis and heart failure.

Citing Articles

Error-corrected ultradeep next-generation sequencing for detection of clonal haematopoiesis and haematological neoplasms - sensitivity, specificity and accuracy.

Tursky M, Artuz C, Rapadas M, Wittert G, Molloy T, Ma D PLoS One. 2025; 20(2):e0318300.

PMID: 40009600 PMC: 11864513. DOI: 10.1371/journal.pone.0318300.

How clonal hematopoiesis promotes inflammation at a single-cell level.

Chavkin N, Evans M, Walsh K Nat Cardiovasc Res. 2024; 2(9):801-802.

PMID: 39196066 DOI: 10.1038/s44161-023-00323-w.

Impact of age and sex on myelopoiesis and inflammation during myocardial infarction.

Kanuri B, Biswas P, Dahdah A, Murphy A, Nagareddy P J Mol Cell Cardiol. 2024; 187:80-89.

PMID: 38163742 PMC: 10922716. DOI: 10.1016/j.yjmcc.2023.11.011.

Role of serum cytokines in the prediction of heart failure in patients with coronary artery disease.

Hou Q, Sun Z, Zhao L, Liu Y, Zhang J, Huang J ESC Heart Fail. 2023; 10(5):3102-3113.

PMID: 37608687 PMC: 10567644. DOI: 10.1002/ehf2.14491.

Inflammasomes and Atherosclerosis: a Mixed Picture.

Tall A, Bornfeldt K Circ Res. 2023; 132(11):1505-1520.

PMID: 37228237 PMC: 10213995. DOI: 10.1161/CIRCRESAHA.123.321637.

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