Gm14230 Controls Tbc1d24 Cytoophidia and Neuronal Cellular Juvenescence

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2021 Apr 22

PMID 33886577

Authors

Takao Morimune

Ayami Tano

Yuya Tanaka

Haruka Yukiue

Takefumi Yamamoto

Ikuo Tooyama

Yoshihiro Maruo

Masaki Nishimura

Masaki Mori

Affiliations

Soon will be listed here.

Abstract

It is not fully understood how enzymes are regulated in the tiny reaction field of a cell. Several enzymatic proteins form cytoophidia, a cellular macrostructure to titrate enzymatic activities. Here, we show that the epileptic encephalopathy-associated protein Tbc1d24 forms cytoophidia in neuronal cells both in vitro and in vivo. The Tbc1d24 cytoophidia are distinct from previously reported cytoophidia consisting of inosine monophosphate dehydrogenase (Impdh) or cytidine-5'-triphosphate synthase (Ctps). Tbc1d24 cytoophidia is induced by loss of cellular juvenescence caused by depletion of Gm14230, a juvenility-associated lncRNA (JALNC) and zeocin treatment. Cytoophidia formation is associated with impaired enzymatic activity of Tbc1d24. Thus, our findings reveal the property of Tbc1d24 to form cytoophidia to maintain neuronal cellular juvenescence.

Citing Articles

Developmental and Epileptic Encephalopathy: Pathogenesis of Intellectual Disability Beyond Channelopathies.

Medyanik A, Anisimova P, Kustova A, Tarabykin V, Kondakova E Biomolecules. 2025; 15(1).

PMID: 39858526 PMC: 11763800. DOI: 10.3390/biom15010133.

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