[Increased Infections by Herpes Simplex Virus Type 1 and Polymicrobials of the Genital Tract, in the General Population of a Spanish Middle City]

Overview

Journal Rev Esp Quimioter

Specialty Pharmacology

Date 2021 Apr 22

PMID 33886170

Citations 2

Authors

C Perez-Torralba

M Ruiz-Olivares

S Sanbonmatsu-Gamez

M Exposito-Ruiz

J M Navarro-Mari

J Gutierrez-Fernandez

Affiliations

Soon will be listed here.

Abstract

Objective: Infections by genitopathogens are a frequent reason for consultation in Primary Health Care and in the specialties of Infectious Diseases, Urology, Gynecology, and Dermatology. The most common causes are opportunistic microorganisms and responsible for sexually transmitted infections associated with unprotected sex. The objective is to determine the microorganisms that cause these infections in patients treated at the Hospital Universitario Virgen de las Nieves in Granada and Neisseria gonorrhoeae susceptibility to antibiotics.

Methods: A transversal-descriptive and retrospective study was carried out, which included the results issued, between January 2018 and December 2019, in the Microbiology Laboratory from all the episodes studied using standardized working procedures.

Results: The most frequently detected microorganisms were Gardnerella vaginalis (23.81%) followed by Candida spp. (20.9%), especially in females, and N. gonorrhoeae (11.36%) and Ureaplasma urealyticum (11.99%), in males. Many times, they were presented in combination. Regarding herpes simplex viruses, infection by both species had a similar prevalence (50%) in males, while type 1 was more prevalent (76.52%) in females. The most active antibiotics against N. gonorrhoeae were cefotaxime (98%) and cefixime (100%). Tetracycline (39.02%) a poorly active antibiotic.

Conclusions: The most frequent pathogens corresponded to those that usually caused infections in females, although N. gonorrhoeae was the most frequent in males and mixed infections are not an accidental finding. HSV-1 infections were more frequent than HSV-2, confirming the trend of a change in the epidemiology of genital herpes.

Citing Articles

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Rosales-Castillo A, Jimenez-Guerra G, Ruiz-Gomez L, Exposito-Ruiz M, Navarro-Mari J, Gutierrez-Fernandez J J Clin Med. 2022; 11(5).

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References

Gupta R, Warren T, Wald A . Genital herpes. Lancet. 2007; 370(9605):2127-37. DOI: 10.1016/S0140-6736(07)61908-4. View

Jordan J, Durso M . Real-time polymerase chain reaction for detecting bacterial DNA directly from blood of neonates being evaluated for sepsis. J Mol Diagn. 2005; 7(5):575-81. PMC: 1867550. DOI: 10.1016/S1525-1578(10)60590-9. View

Foronda-Garcia-Hidalgo C, Liebana-Martos C, Gutierrez-Soto B, Exposito-Ruiz M, Navarro-Mari J, Gutierrez-Fernandez J . [Prevalence among males from the general population of agents responsible of not ulcerative genital tract infections, assisted in specialized care]. Rev Esp Quimioter. 2019; 32(6):545-550. PMC: 6913070. View

Ruiz-Olivares M, Foronda-Garcia-Hidalgo C, Sanbonmatsu-Gamez S, Gutierrez-Fernandez J . [Recent prevalence among females from the general population of agents responsible for sexually transmitted infections and other genital infections]. Aten Primaria. 2020; 52(10):799-801. PMC: 8054292. DOI: 10.1016/j.aprim.2019.11.009. View

Magdaleno-Tapial J, Hernandez-Bel P, Valenzuela-Onate C, Ortiz-Salvador J, Garcia-Legaz-Martinez M, Martinez-Domenech A . Genital Infection With Herpes Simplex Virus Type 1 and Type 2 in Valencia, Spain: A Retrospective Observational Study. Actas Dermosifiliogr (Engl Ed). 2019; 111(1):53-58. DOI: 10.1016/j.ad.2019.06.002. View

Caballero-Mateos A, Lopez de Hierro-Ruiz M, Rodriguez-Dominguez M, Galan-Montemayor J, Gutierrez-Fernandez J . Co-infection by lymphogranuloma venereum and Haemophilus parainfluenzae during an episode of proctitis. Gastroenterol Hepatol. 2017; 41(2):107-109. DOI: 10.1016/j.gastrohep.2016.12.007. View

Macho-Aizpurua M, Imaz-Perez M, Alava-Menica J, Hernandez-Ragpa L, Lopez-de-Munain-Lopez M, Camara-Perez M . Characteristics of genital herpes in Bilbao (Northern Spain): 12-year retrospective study. Enferm Infecc Microbiol Clin (Engl Ed). 2020; 39(5):234-240. DOI: 10.1016/j.eimc.2020.04.014. View

Lopez-Vicente J, Rodriguez-Alcalde D, Hernandez-Villalba L, Moreno-Sanchez D, Lumbreras-Cabrera M, Barros-Aguado C . Proctitis as the clinical presentation of lymphogranuloma venereum, a re-emerging disease in developed countries. Rev Esp Enferm Dig. 2014; 106(1):59-62. DOI: 10.4321/s1130-01082014000100011. View

Jesus de la Calle I, Jesus De La Calle M . [Bacterial vaginosis]. Med Clin (Barc). 2009; 133(20):789-97. DOI: 10.1016/j.medcli.2008.11.043. View

10.

Hart T, Tang W, Mansoor S, Chio M, Barkham T . Mycoplasma genitalium in Singapore is associated with Chlamydia trachomatis infection and displays high macrolide and Fluoroquinolone resistance rates. BMC Infect Dis. 2020; 20(1):314. PMC: 7189604. DOI: 10.1186/s12879-020-05019-1. View

11.

Vazquez F, Otero L, Ordas J, Junquera M, Varela J . [Up to date in sexually transmitted infections: epidemiology, diagnostic approaches and treatments]. Enferm Infecc Microbiol Clin. 2004; 22(7):392-411. DOI: 10.1016/s0213-005x(04)73123-7. View

12.

Lopez-de-Munain J, Camara-Perez M, Imaz-Perez M, Pereda-Berroeta J, Lopez-Azcarreta I, Munoz-Sanchez J . Chlamydia trachomatis re-infection in Spain: A STI clinic-based cohort study. Enferm Infecc Microbiol Clin. 2016; 35(3):165-173. DOI: 10.1016/j.eimc.2016.08.011. View

13.

Fairhead C, Hampson A, Dwyer-Hemmings L, Vasdev N . Is Non-Chlamydial Non-Gonococcal Urethritis Associated with Significant Clinical Complications in Men? A Systematic Review. Curr Urol. 2020; 14(1):1-13. PMC: 7206600. DOI: 10.1159/000499266. View

14.

Taylor S . Cervicitis of unknown etiology. Curr Infect Dis Rep. 2014; 16(7):409. DOI: 10.1007/s11908-014-0409-x. View

15.

Calatrava-Hernandez E, Foronda-Garcia-Hidalgo C, Gutierrez-Fernandez J . Resistance, molecular characterization and viability of Neisseria gonorrhoeae recent clinical isolates. Med Clin (Barc). 2020; 156(5):249-250. DOI: 10.1016/j.medcli.2020.01.007. View

16.

Navarrete P, Dominguez M, Castro E, Zemelman R . [Evaluation of Nugent and Amsel criteria for the diagnosis of bacterial vaginosis]. Rev Med Chil. 2000; 128(7):767-71. View

17.

Carrillo-Avila J, Serrano-Garcia M, Fernandez-Parra J, Sorlozano-Puerto A, Navarro-Mari J, Stensvold C . Prevalence and genetic diversity of Trichomonas vaginalis in the general population of Granada and co-infections with Gardnerella vaginalis and Candida species. J Med Microbiol. 2017; 66(10):1436-1442. DOI: 10.1099/jmm.0.000603. View

18.

Lopez de Munain J . Epidemiology and current control of sexually transmitted infections. The role of STI clinics. Enferm Infecc Microbiol Clin (Engl Ed). 2018; 37(1):45-49. DOI: 10.1016/j.eimc.2018.10.015. View

19.

Day M, Spiteri G, Jacobsson S, Woodford N, Amato-Gauci A, Cole M . Stably high azithromycin resistance and decreasing ceftriaxone susceptibility in Neisseria gonorrhoeae in 25 European countries, 2016. BMC Infect Dis. 2018; 18(1):609. PMC: 6276195. DOI: 10.1186/s12879-018-3528-4. View