Nanotherapeutic-directed Approaches to Analgesia

Overview

Journal Trends Pharmacol Sci

Specialty Pharmacology

Date 2021 Apr 22

PMID 33883067

Citations 5

Authors

Liudmila L Mazaleuskaya

Vladimir R Muzykantov

Garret A FitzGerald

Affiliations

Soon will be listed here.

Abstract

The ongoing opioid crisis highlighted the need for non-steroidal anti-inflammatory drugs (NSAIDs), nonaddictive analgesics against pain, fever, and inflammation. However, NSAIDs may cause gastrointestinal and cardiovascular adverse effects. To avoid systemic toxicity and deliver drugs to diseased tissues, nanotechnology methods of NSAID encapsulation have been reported and some have reached clinical development. Currently, 57 micro- and nanodrugs are approved by the US FDA. Already approved nanoanalgesics have revealed superior efficacy or reduced toxicity compared with placebo or lower doses of systemically administered active comparators. In this review, the evidence for approval of the marketed nanodrugs will be discussed, with a focus on therapies for pain and inflammation. Nanomedicine remains an attractive field for the development of targeted analgesics.

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