Titanocene-Catalyzed [2+2] Cycloaddition of Bisenones and Comparison with Photoredox Catalysis and Established Methods

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2021 Apr 19

PMID 33871126

Citations 5

Authors

Zhenhua Zhang

Julius B Stuckrath

Stefan Grimme

Andreas Gansauer

Affiliations

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Abstract

Cp Ti(TFA) is a broadly applicable catalyst for the [2+2] cycloaddition of bisenones by inner-sphere electron transfer. The attractiveness of this mechanism is shown by comparison with outer-sphere ET methods. DFT calculations show that the reaction proceeds through a unique unfavorable 5-exo (the rate-determining step) and a favorable 4-exo cyclization.

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