Compartments and Connections Within the Germinal Center

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2021 Apr 19

PMID 33868306

Citations 6

Authors

Domenick E Kennedy

Marcus R Clark

Affiliations

Soon will be listed here.

Abstract

Protective high affinity antibody responses emerge through an orchestrated developmental process that occurs in germinal centers (GCs). While GCs have been appreciated since 1930, a wealth of recent progress provides new insights into the molecular and cellular dynamics governing humoral immunity. In this review, we highlight advances that demonstrate that fundamental GC B cell function, selection, proliferation and SHM occur within distinct cell states. The resulting new model provides new opportunities to understand the evolution of immunity in infectious, autoimmune and neoplastic diseases.

Citing Articles

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STAT3 signaling in B cells controls germinal center zone organization and recycling.

Fike A, Chodisetti S, Wright N, Bricker K, Domeier P, Maienschein-Cline M Cell Rep. 2023; 42(5):112512.

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