Translating the Transcriptome: Sex Differences in the Mechanisms of Depression and Stress, Revisited

Overview

Journal Biol Psychiatry

Publisher Elsevier

Specialty Psychiatry

Date 2021 Apr 18

PMID 33865609

Citations 12

Authors

Jennifer R Rainville

Timothy Lipuma

Georgia E Hodes

Affiliations

Soon will be listed here.

Abstract

The past decade has produced a plethora of studies examining sex differences in the transcriptional profiles of stress and mood disorders. As we move forward from accepting the existence of extensive molecular sex differences in the brain to exploring the purpose of these sex differences, our approach must become more systemic and less reductionist. Earlier studies have examined specific brain regions and/or cell types. To use this knowledge to develop the next generation of personalized medicine, we need to comprehend how transcriptional changes across the brain and/or the body relate to each other. We provide an overview of the relationships between baseline and depression/stress-related transcriptional sex differences and explore contributions of preclinically identified mechanisms and their impacts on behavior.

Citing Articles

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Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings.

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