Defensive Impact of Propolis Against CCl Actuated Rats' Testicular Damage

Overview

Journal J Adv Vet Anim Res

Specialty Veterinary Medicine

Date 2021 Apr 16

PMID 33860015

Citations 5

Authors

Aml S Hashem

Affiliations

Soon will be listed here.

Abstract

Objective: The paper's primary goal is to report the devastating impact of carbon tetrachloride (CCl) on rat testicular tissue and the possible protecting function of propolis against CCl based on its free radical scavenging and inflammatory relief properties.

Materials And Methods: A total of 24 adult male albino rats had been classified into four groups (six rats/group). Rats of group 1 served as control, whereas groups 2-4 received propolis (200 mg/kg/day), CCl (3 ml/kg/day), and propolis/CCl, respectively. After 4 weeks, the collected sera were applied for the estimation of lipid profile and sex hormones. Also, histopathological picture, malondialdehyde, and tumor necrosis factor alpha (TNFα) gene profile was measured in collected testicular tissues.

Results: The present information revealed a noteworthy change ( < 0.05) in lipid profile, decrease in testicular weight, testosterone, antioxidants values along with a prominent increase ( < 0.05) in estradiol, lipid peroxidation values, and expression of TNFα in rats administrated with CCl compared to control. Moreover, the histopathological profile showed the degeneration of the epithelium. Interestingly, propolis attenuated the destructive effect of CCl on rat testes.

Conclusion: The examined dose of propolis reduced oxidation, and inflammatory reactions resulted from CCl exposure and proved that it might have a helpful part in free radicals interceded diseases.

Citing Articles

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Alpha-pinene alleviates CCl-induced renal and testicular injury in rats by targeting oxidative stress, inflammation, and apoptosis.

Noroozi F, Asle-Rousta M, Amini R, Sahraeian Z Iran J Basic Med Sci. 2024; 27(6):678-684.

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An Innovative Use of Propolis in the Production of Dipping Sauce Powder as a Functional Food to Mitigate Testicular Toxicity Induced by Cadmium Chloride: Technological and Biological Evidence.

Sheir M, Serrapica F, Ahmed R Foods. 2023; 12(16).

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Banihani S Clin Exp Reprod Med. 2023; 50(1):12-18.

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