Molecular and Cellular Mechanisms of the Effects of Propolis in Inflammation, Oxidative Stress and Glycemic Control in Chronic Diseases

Overview

Journal Nutr Metab (Lond)

Publisher Biomed Central

Date 2020 Aug 21

PMID 32817750

Citations 27

Authors

Naseh Pahlavani

Mahsa Malekahmadi

Safieh Firouzi

Daryoush Rostami

Alireza Sedaghat

Ahmad Bagheri Moghaddam

Gordon A Ferns

Jamshid Gholizadeh Navashenaq

Reza Reazvani

Mohammad Safarian

Majid Ghayour-Mobarhan

Affiliations

Soon will be listed here.

Abstract

Propolis is a sticky, resinous material gather from plants and is blended with wax and other constituents. It is reported to have anti-inflammatory, anti-oxidative and blood glucose-lowering properties. This review aims to summarise evidences for the cellular and molecular mechanism of Propolis in inflammation, oxidative stress, and glycemic control. Propolis stimulate the production and secretion of anti-inflammatory cytokines and to inhibit the production of inflammatory cytokines and due to its various antioxidant and poly-phenolic compounds may has a role in control and treating some of the chronic diseases. Most studies have shown that Propolis may affect metabolic factors including plasma insulin levels, and it has proposed that it could be used in the prevention and treatment of T2D Mellitus. In general, to demonstrate the definite effects of Propolis on chronic diseases, more studies are required using larger sample sizes and various doses of Propolis, using better characterized and standardized agents.

Citing Articles

Propolis: A Natural Substance with Multifaceted Properties and Activities.

Martinotti S, Bonsignore G, Ranzato E Int J Mol Sci. 2025; 26(4).

PMID: 40003984 PMC: 11855500. DOI: 10.3390/ijms26041519.

Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative Review.

Bertolucci V, Ninomiya A, Longato G, Kaneko L, Nonose N, Scariot P Antioxidants (Basel). 2025; 14(1).

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Propolis does not significantly modulate immune function in an older population: A preliminary study.

Pu L, Wang Y, Pang W, Wei J, Wu J, Guo C Heliyon. 2025; 10(24):e41056.

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Effects of aqueous and ethanolic extracts of Chinese propolis on dental pulp stem cell viability, migration and cytokine expression.

Park H, Dinh Y, Yesares Rubi P, Gibbs J, Michot B PeerJ. 2024; 12:e18742.

PMID: 39713129 PMC: 11662894. DOI: 10.7717/peerj.18742.

Effects of Propolis Consumption on Liver Enzymes and Obesity Indices in Adults: A Systematic Review and Dose-Response Meta-Analysis.

Aliakbarian M, Shahraki Jazinaki M, Bahari H, Rashidmayvan M, Golafrouz H, Khodashahi R Curr Dev Nutr. 2024; 8(9):104438.

PMID: 39296926 PMC: 11407979. DOI: 10.1016/j.cdnut.2024.104438.

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