β-Hemolysin Up-Regulates the Expression of IFN-γ by Human CD56 NK Cells

Overview

Journal Front Cell Infect Microbiol

Specialties Cell Biology
Infectious Diseases
Microbiology

Date 2021 Apr 15

PMID 33854984

Citations 5

Authors

Zhangchun Guan

Yu Liu

Chenghua Liu

Huiting Wang

Jiannan Feng

Guang Yang

Affiliations

Soon will be listed here.

Abstract

IFN-γ is produced upon stimulation with and may play a detrimental role during infection. However, whether hemolysins play a role in the mechanism of IFN-γ production has not been fully characterized. In this study, we demonstrated that Hlb, one of the major hemolysins of , upregulated IFN-γ production by CD56 NK cells from human peripheral blood mononuclear cells (PBMCs). Further investigation showed that Hlb increased calcium influx and induced phosphorylation of ERK1/2. Either blocking calcium or specifically inhibiting phosphorylation of ERK1/2 decreased the production of IFN-γ induced by Hlb. Moreover, we found that this process was dependent on the sphingomyelinase activity of Hlb. Our findings revealed a novel mechanism of IFN-γ production in NK cells induced by Hlb, which may be involved in the pathogenesis of .

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