Studies on Selected Jordanian Plants As Dipeptidyl Peptidase-IV Inhibitors for Management of Diabetes Mellitus

Diabetes mellitus is a chronic disease characterized by hyperglycemia mainly because of the absolute or relative deficiency of insulin hormone. The dipeptidyl peptidase-IV inhibitors represent a class of glucose-lowering agents potentiating the action of the incretin hormones glucagon-likepeptide-1 and glucose dependent insulinotropic polypeptide, which are secreted from the intestinal endocrine cells in response to food ingestion to stimulate insulin secretion from pancreatic beta cells. Natural products have been traditionally used for curing many diseases. In this study, biological evaluation of the isolated compounds calotoxin, calotropin, pectolinarigenin, apigenin7-O-(3",6"-di-O-E-p-coumaroyl)-β-glycoside and extracts of , , , and showed potential inhibitory activity, where the butanol extract of was found to have 85.3% inhibition of dipeptidyl peptidase-IV at 0.2 mg/100 µL concentration.