Studies on Leaf Extracts As Inhibitors of Key Enzymes Linked to Diabetes Mellitus

Overview

Journal Iran J Pharm Res

Publisher Brieflands

Specialty Pharmacology

Date 2017 Feb 24

PMID 28228802

Citations 10

Authors

Mutiu Idowu Kazeem

Ayuva Mercy Mayaki

Bimpe Folashade Ogungbe

Anthony Babajide Ojekale

Affiliations

Soon will be listed here.

Abstract

The side effects associated with the usage of synthetic antidiabetic drugs make it imperative to search for alternative drugs from medicinal plants. Therefore, this study was aimed at evaluating the α-amylase and α-glucosidase inhibitory potential of leaf, as well as its possible mode of inhibiting these enzymes. Acetone, aqueous and ethanolic extracts of leaf was subjected to standard enzymes' inhibitory assay using porcine pancreatic α-amylase and rat intestinal α-glucosidase. Results obtained showed that out of all the extracts tested, ethanolic and aqueous extracts possessed the best inhibition of α-amylase (IC 7.80 mg/mL) and α-glucosidase (3.25 mg/mL) respectively. The kinetic analysis of the mode of inhibition of these enzymes by the leaf extracts of , revealed that these extracts inhibited both enzymes in a non-competitive manner. It is speculated that the α-amylase and α-glucosidase inhibitory properties of leaf extracts of may be due to the presence of some phytochemicals such as flavonoids, tannins and saponins in the plant. It can be concluded from this study that the extracts could serve as source of antidiabetic agents which may act through the inhibition of carbohydrate hydrolyzing enzymes, α-amylase and α-glucosidase.

Citing Articles

In Vitro and in Silico Analysis of α -Amylase Inhibitory Activity of Ethanolic Extract of Leaves.

Yadav C, Kc S, Thapa S Glob Adv Integr Med Health. 2024; 13:27536130241270621.

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Calotropis procera and the Pharmacological Properties of Its Aqueous Leaf Extract: A Review.

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Molecular Structure-Based Screening of the Constituents of Identifies Potential Inhibitors of Diabetes Mellitus Target Alpha Glucosidase.

Adinortey C, Kwarko G, Koranteng R, Boison D, Obuaba I, Wilson M Curr Issues Mol Biol. 2022; 44(2):963-987.

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Bio-Guided Isolation of Two New Hypoglycemic Triterpenoid Saponins from .

Huang D, Du Z, Chen Y, Dong Z, Wang X, Li M Drug Des Devel Ther. 2021; 15:5001-5010.

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