H NMR Metabolomics and Full-Length RNA-Seq Reveal Effects of Acylated and Nonacylated Anthocyanins on Hepatic Metabolites and Gene Expression in Zucker Diabetic Fatty Rats

Overview

Journal J Agric Food Chem

Specialties Chemistry
Nutritional Sciences

Date 2021 Apr 9

PMID 33835816

Citations 3

Authors

Kang Chen

Xuetao Wei

Raghunath Pariyani

Maaria Kortesniemi

Yumei Zhang

Baoru Yang

Affiliations

Soon will be listed here.

Abstract

Anthocyanins have been reported to possess antidiabetic effects. Recent studies indicate acylated anthocyanins have better stability and antioxidative activity compared to their nonacylated counterparts. This study compared the effects of nonacylated and acylated anthocyanins on hepatic gene expression and metabolic profile in diabetic rats, using full-length transcriptomics and H NMR metabolomics. Zucker diabetic fatty (ZDF) rats were fed with nonacylated anthocyanin extract from bilberries (NAAB) or acylated anthocyanin extract from purple potatoes (AAPP) at daily doses of 25 and 50 mg/kg body weight for 8 weeks. Both anthocyanin extracts restored the levels of multiple metabolites (glucose, lactate, alanine, and pyruvate) and expression of genes (, , , and ) involved in glycolysis and gluconeogenesis. AAPP decreased the hepatic glutamine level. NAAB regulated the expression of , , and , whereas AAPP modified the expression of , , , and . This study indicated different effects of AAPP and NAAB on the hepatic transcriptomic and metabolic profiles of diabetic rats.

Citing Articles

Anthocyanins as Promising Molecules Affecting Energy Homeostasis, Inflammation, and Gut Microbiota in Type 2 Diabetes with Special Reference to Impact of Acylation.

Chen K, Kortesniemi M, Linderborg K, Yang B J Agric Food Chem. 2022; 71(2):1002-1017.

PMID: 36515085 PMC: 9853865. DOI: 10.1021/acs.jafc.2c05879.

Effect of Acylated and Nonacylated Anthocyanins on Urine Metabolic Profile during the Development of Type 2 Diabetes in Zucker Diabetic Fatty Rats.

Chen K, Wei X, Zhang J, Kortesniemi M, Zhang Y, Yang B J Agric Food Chem. 2022; 70(48):15143-15156.

PMID: 36410712 PMC: 9732871. DOI: 10.1021/acs.jafc.2c06802.

The Effect of Polyphenol Extract from Rosa Roxburghii Fruit on Plasma Metabolome and Gut Microbiota in Type 2 Diabetic Mice.

Wang H, Chen Z, Wang M, Long M, Ren T, Chen C Foods. 2022; 11(12).

PMID: 35741945 PMC: 9222671. DOI: 10.3390/foods11121747.

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