The Cross-sectional Interplay Between Neurochemical Profile and Brain Connectivity

Overview

Journal Hum Brain Mapp

Publisher Wiley

Specialty Neurology

Date 2021 Apr 9

PMID 33835605

Citations 7

Authors

George Zacharopoulos

Uzay Emir

Roi Cohen Kadosh

Affiliations

Soon will be listed here.

Abstract

Neurochemical profile and brain connectivity are both critical aspects of brain function. However, our knowledge of their interplay across development is currently poor. We combined single-voxel magnetic resonance spectroscopy and resting functional magnetic resonance imaging in a cross-sectional sample spanning from childhood to adulthood which was reassessed in ~1.5 years (N = 293). We revealed the developmental trajectories of 20 neurochemicals in two key developmental brain regions (the intraparietal sulcus, IPS, and the middle frontal gyrus, MFG). We found that certain neurochemicals exhibited similar developmental trajectories across the two regions, while other trajectories were region-specific. Crucially, we mapped the connectivity of the brain regions IPS and MFG to the rest of the brain across development as a function of regional glutamate and GABA concentration. We demonstrated that glutamate concentration within the IPS is modulated by age in explaining IPS connectivity with frontal, temporal and parietal regions. In mature participants, higher glutamate within the IPS was related to more negative connectivity while the opposite pattern was found for younger participants. Our findings offer specific developmental insights on the interplay between the brain's resting activity and the glutamatergic system both of which are crucial for regulating normal functioning and are dysregulated in several clinical conditions.

Citing Articles

Glutamate measurements using edited MRS.

Saleh M, Prescot A, Chang L, Cloak C, Cunningham E, Subramaniam P Magn Reson Med. 2023; 91(4):1314-1322.

PMID: 38044723 PMC: 10865745. DOI: 10.1002/mrm.29929.

Dissecting the chain of information processing and its interplay with neurochemicals and fluid intelligence across development.

Zacharopoulos G, Sella F, Emir U, Cohen Kadosh R Elife. 2023; 12.

PMID: 37772958 PMC: 10541179. DOI: 10.7554/eLife.84086.

Human neuronal excitation/inhibition balance explains and predicts neurostimulation induced learning benefits.

van Bueren N, van der Ven S, Hochman S, Sella F, Cohen Kadosh R PLoS Biol. 2023; 21(8):e3002193.

PMID: 37651315 PMC: 10470965. DOI: 10.1371/journal.pbio.3002193.

The effect of parietal glutamate/GABA balance on test anxiety levels in early childhood in a cross-sectional and longitudinal study.

Zacharopoulos G, Sella F, Cohen Kadosh K, Emir U, Cohen Kadosh R Cereb Cortex. 2021; 32(15):3243-3253.

PMID: 34963130 PMC: 9340388. DOI: 10.1093/cercor/bhab412.

Neurochemical abnormalities in chronic fatigue syndrome: a pilot magnetic resonance spectroscopy study at 7 Tesla.

Godlewska B, Williams S, Emir U, Chen C, Sharpley A, Goncalves A Psychopharmacology (Berl). 2021; 239(1):163-171.

PMID: 34609538 PMC: 8770374. DOI: 10.1007/s00213-021-05986-6.

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