Biosynthesis of Cyclophane-Containing Hirsutellone Family of Fungal Natural Products

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2021 Apr 9

PMID 33834778

Citations 10

Authors

Masao Ohashi

Thomas B Kakule

Man-Cheng Tang

Cooper S Jamieson

Mengting Liu

Yi-Lei Zhao

Kendall N Houk

Yi Tang

Affiliations

Soon will be listed here.

Abstract

Hirsutellones are fungal natural products containing a macrocyclic cyclophane connected to a decahydrofluorene ring system. We have elucidated the biosynthetic pathway for pyrrocidine B () and GKK1032 A (). Two small hypothetical proteins, an oxidoreductase and a lipocalin-like protein, function cooperatively in the oxidative cyclization of the cyclophane, while an additional hypothetical protein in the pyrrocidine pathway catalyzes the specific cycloaddition to form the fused decahydrofluorene.

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