Total Synthesis of Hirsutellone B Via Ullmann-type Direct 13-membered Macrocyclization

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2011 Nov 2

PMID 22040033

Citations 15

Authors

Hiromi Uchiro

Ryo Kato

Yuuki Arai

Miki Hasegawa

Yu Kobayakawa

Affiliations

Soon will be listed here.

Abstract

Total synthesis of Hirsutellone B has been achieved by a convergent synthetic strategy. This synthesis features direct construction of the highly strained 13-membered macrocycle of Hirsutellone B utilizing the Ullmann-type reaction. To the best of our knowledge, this is the first application of macrocyclization utilizing an intramolecular Ullmann-type reaction between an aliphatic alcohol and aryl halide.

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