Mass Spectrometry-based Metabolomics in Translational Research

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2021 Apr 9

PMID 33834448

Citations 13

Authors

Su Jung Kim

Ha Eun Song

Hyo Yeong Lee

Hyun Ju Yoo

Affiliations

Soon will be listed here.

Abstract

Metabolomics is the systematic study of metabolite profiles of complex biological systems, and involves the systematic identification and quantification of metabolites. Metabolism is integrated with all biochemical reactions in biological systems; thus metabolite profiles provide collective information on biochemical processes induced by genetic or environmental perturbations. Transcriptomes or proteomes may not be functionally active and not always reflect phenotypic variations. The metabolome, however, consists of the biomolecules closest to the phenotype of living organisms, and is often called the molecular phenotype of biological systems. Thus, metabolome alterations can easily result in disease states, providing important clues to understand pathophysiological mechanisms contributing to various biomedical symptoms. The metabolome and metabolomics have been emphasized in translational research related to biomarker discovery, drug target discovery, drug responses, and disease mechanisms. This review describes the basic concepts, workflows, and applications of mass spectrometry-based metabolomics in translational research.

Citing Articles

Comprehensive Analysis of Metabolic Changes in Mice Exposed to Corilagin Based on GC-MS Analysis.

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Patterns of infant fecal metabolite concentrations and social behavioral development in toddlers.

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Metabolomic profiles of ovariectomized mice and their associations with body composition and frailty-related parameters in postmenopausal women.

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