The Role of Neurotrophic Factors in Pathophysiology of Major Depressive Disorder

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2021 Apr 9

PMID 33834404

Citations 12

Authors

Meysam Amidfar

Gislaine Zilli Reus

Airam Barbosa de Moura

Joao Quevedo

Yong-Ku Kim

Affiliations

Soon will be listed here.

Abstract

According to the neurotrophic hypothesis of major depressive disorder (MDD), impairment in growth factor signaling might be associated with the pathology of this illness. Current evidence demonstrates that impaired neuroplasticity induced by alterations of neurotrophic growth factors and related signaling pathways may be underlying to the pathophysiology of MDD. Brain-derived neurotrophic factor (BDNF) is the most studied neurotrophic factor involved in the neurobiology of MDD. Nevertheless, developing evidence has implicated other neurotrophic factors, including neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), nerve growth factor (NGF), vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), glial cell-derived neurotrophic factor (GDNF), and fibroblast growth factor (FGF) in the MDD pathophysiology. Here, we summarize the current literature on the involvement of neurotrophic factors and related signaling pathways in the pathophysiology of MDD.

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