DNA Origami-Enabled Plasmonic Sensing

Overview

Journal J Phys Chem C Nanomater Interfaces

Publisher American Chemical Society

Date 2021 Apr 8

PMID 33828635

Citations 12

Authors

Mihir Dass

Fatih N Gur

Karol Kolataj

Maximilian J Urban

Tim Liedl

Affiliations

Soon will be listed here.

Abstract

The reliable programmability of DNA origami makes it an extremely attractive tool for bottom-up self-assembly of complex nanostructures. Utilizing this property for the tuned arrangement of plasmonic nanoparticles holds great promise particularly in the field of biosensing. Plasmonic particles are beneficial for sensing in multiple ways, from enhancing fluorescence to enabling a visualization of the nanoscale dynamic actuation via chiral rearrangements. In this Perspective, we discuss the recent developments and possible future directions of DNA origami-enabled plasmonic sensing systems. We start by discussing recent advancements in the area of fluorescence-based plasmonic sensing using DNA origami. We then move on to surface-enhanced Raman spectroscopy sensors followed by chiral sensing, both utilizing DNA origami nanostructures. We conclude by providing our own views on the future prospects for plasmonic biosensors enabled using DNA origami.

Citing Articles

Label-free (fluorescence-free) sensing of a single DNA molecule on DNA origami using a plasmon-enhanced WGM sensor.

Ghamari S, Chiarelli G, Kolataj K, Subramanian S, Acuna G, Vollmer F Nanophotonics. 2025; 14(2):253-262.

PMID: 39927203 PMC: 11806501. DOI: 10.1515/nanoph-2024-0560.

Molecular Origami: Designing Functional Molecules of the Future.

Ishida H, Ito T, Kuzuya A Molecules. 2025; 30(2).

PMID: 39860111 PMC: 11768013. DOI: 10.3390/molecules30020242.

Label-free optical biosensors in the pandemic era.

Nava G, Zanchetta G, Giavazzi F, Buscaglia M Nanophotonics. 2024; 11(18):4159-4181.

PMID: 39634532 PMC: 11502114. DOI: 10.1515/nanoph-2022-0354.

From Bulk to Single Molecules: Surface-Enhanced Raman Scattering of Cytochrome C Using Plasmonic DNA Origami Nanoantennas.

Mostafa A, Kanehira Y, Tapio K, Bald I Nano Lett. 2024; 24(23):6916-6923.

PMID: 38829305 PMC: 11177308. DOI: 10.1021/acs.nanolett.4c00834.

DNA T-shaped crossover tiles for 2D tessellation and nanoring reconfiguration.

Yang Q, Chang X, Lee J, Saji M, Zhang F Nat Commun. 2023; 14(1):7675.

PMID: 37996416 PMC: 10667507. DOI: 10.1038/s41467-023-43558-8.

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