Mechanisms Implicated in the Contralateral Effect in the Central Nervous System After Unilateral Injury: Focus on the Visual System

Overview

Journal Neural Regen Res

Date 2021 Apr 5

PMID 33818483

Citations 14

Authors

Fernando Lucas-Ruiz

Caridad Galindo-Romero

Virginia Albaladejo-Garcia

Manuel Vidal-Sanz

Marta Agudo-Barriuso

Affiliations

Soon will be listed here.

Abstract

The retina, as part of the central nervous system is an ideal model to study the response of neurons to injury and disease and to test new treatments. During the last decade is becoming clear that unilateral lesions in bilateral areas of the central nervous system trigger an inflammatory response in the contralateral uninjured site. This effect has been better studied in the visual system where, as a rule, one retina is used as experimental and the other as control. Contralateral retinas in unilateral models of retinal injury show neuronal degeneration and glial activation. The mechanisms by which this adverse response in the central nervous system occurs are discussed in this review, focusing primarily on the visual system.

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