Assessment of the Abuse Potential of Methamnetamine in Rodents: a Behavioral Pharmacology Study

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 2021 Apr 3

PMID 33811503

Citations 1

Authors

Dong-Hyun Youn

Jin Mook Kim

Young-Ki Hong

Seo-In Park

Jin-Moo Lee

Young-Hoon Kim

Chang Won Park

Mi Sun Kang

Affiliations

Soon will be listed here.

Abstract

Rationale: Methamnetamine (MNA; PAL-1046) is a new psychoactive substance that acts as a full biogenic amine transporter (BAT) substrate. BAT substrates promote neurotransmitter release from the nerve terminal and can be abused as stimulants. However, scientific information on the abuse potential of methamnetamine is lacking.

Objective: We evaluated the abuse liability of methamnetamine.

Methods: The effective dose range of methamnetamine was determined using a climbing behavior test. The rewarding effect and reinforcing effect of the test compound were evaluated in mice by conditioned place preference (CPP) testing and self-administration (SA) testing at the selected doses. Dopamine level changes were analyzed using synaptosomes and in vivo microdialysis to investigate the effects of methamnetamine on the central nervous system. Drug discrimination experiments were used to examine the potential similarity of the interoceptive effects of methamnetamine and cocaine.

Results: A significant response was observed in the climbing behavior test with 10 and 40 mg/kg intraperitoneally administered methamnetamine. In the CPP test, mice intraperitoneally administered methamnetamine (10 and 20 mg/kg) showed a significant preference for the drug-paired compartment. In the SA test, mice that intravenously received 1 mg/kg/infusion showed significant active-lever responses. Dopamine was significantly increased in synaptosomes and in in vivo microdialysis tests. Furthermore, methamnetamine showed cross-generalization with cocaine in a dose-dependent manner.

Conclusions: Methamnetamine exhibits interceptive stimulus properties similar to those of cocaine and induces rewarding and reinforcing effects, suggesting its dependence liability potential.

Citing Articles

Amphetamine-induced prolonged disturbances in tissue levels of dopamine and serotonin in the rat brain.

Taracha E, Czarna M, Turzynska D, Maciejak P Pharmacol Rep. 2023; 75(3):596-608.

PMID: 36944909 PMC: 10227166. DOI: 10.1007/s43440-023-00472-6.

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