Metabolic Reprogramming in Cancer: Role of HPV 16 Variants

Overview

Journal Pathogens

Date 2021 Apr 3

PMID 33809480

Citations 14

Authors

Adan Arizmendi-Izazaga

Napoleon Navarro-Tito

Hilda Jimenez-Wences

Miguel A Mendoza-Catalan

Dinorah N Martinez-Carrillo

Ana E Zacapala-Gomez

Monserrat Olea-Flores

Roberto Dircio-Maldonado

Francisco I Torres-Rojas

Diana G Soto-Flores

Berenice Illades-Aguiar

Julio Ortiz-Ortiz

Affiliations

Soon will be listed here.

Abstract

Metabolic reprogramming is considered one of the hallmarks in cancer and is characterized by increased glycolysis and lactate production, even in the presence of oxygen, which leads the cancer cells to a process called "aerobic glycolysis" or "Warburg effect". The E6 and E7 oncoproteins of human papillomavirus 16 (HPV 16) favor the Warburg effect through their interaction with a molecule that regulates cellular metabolism, such as p53, retinoblastoma protein (pRb), c-Myc, and hypoxia inducible factor 1α (HIF-1α). Besides, the impact of the E6 and E7 variants of HPV 16 on metabolic reprogramming through proteins such as HIF-1α may be related to their oncogenicity by favoring cellular metabolism modifications to satisfy the energy demands necessary for viral persistence and cancer development. This review will discuss the role of HPV 16 E6 and E7 variants in metabolic reprogramming and their contribution to developing and preserving the malignant phenotype of cancers associated with HPV 16 infection.

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