The Role of P53 Up-regulated Modulator of Apoptosis (PUMA) in Ovarian Development, Cardiovascular and Neurodegenerative Diseases

Overview

Journal Apoptosis

Publisher Springer

Date 2021 Mar 30

PMID 33783663

Citations 35

Authors

Mei Li

Affiliations

Soon will be listed here.

Abstract

P53 up-regulated modulator of apoptosis (PUMA), a pro-apoptotic BCL-2 homology 3 (BH3)-only member of the BCL-2 family, is a direct transcriptional target of P53 that elicits mitochondrial apoptosis under treatment with radiation and chemotherapy. It also induces excessive apoptosis in cardiovascular and/or neurodegenerative diseases. PUMA has been found to play a critical role in ovarian apoptosis. In the present paper, we review the progress of the study in PUMA over the past two decades in terms of its inducement and/or amplification of programmed cell death and describe recent updates to the understanding of both P53-dependent and P53-independent PUMA-mediated apoptotic pathways that are implicated in physiology and pathology, including the development of the ovary and cardiovascular and neurodegenerative diseases. We propose that PUMA may be a key regulator during ovary development, provide a model for PUMA-mediated apoptotic pathways, including intrinsic and extrinsic apoptotic pathways.

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References

Hollville E, Romero S, Deshmukh M . Apoptotic cell death regulation in neurons. FEBS J. 2019; 286(17):3276-3298. PMC: 6718311. DOI: 10.1111/febs.14970. View

Steckley D, Karajgikar M, Dale L, Fuerth B, Swan P, Drummond-Main C . Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis. J Neurosci. 2007; 27(47):12989-99. PMC: 6673275. DOI: 10.1523/JNEUROSCI.3400-07.2007. View

Kaverina N, Kadagidze Z, Borovjagin A, Karseladze A, Kim C, Lesniak M . Tamoxifen overrides autophagy inhibition in Beclin-1-deficient glioma cells and their resistance to adenovirus-mediated oncolysis via upregulation of PUMA and BAX. Oncogene. 2018; 37(46):6069-6082. DOI: 10.1038/s41388-018-0395-9. View

Sanphui P, Biswas S . FoxO3a is activated and executes neuron death via Bim in response to β-amyloid. Cell Death Dis. 2013; 4:e625. PMC: 3674357. DOI: 10.1038/cddis.2013.148. View

David C, Massague J . Contextual determinants of TGFβ action in development, immunity and cancer. Nat Rev Mol Cell Biol. 2018; 19(7):419-435. PMC: 7457231. DOI: 10.1038/s41580-018-0007-0. View

Akhter R, Sanphui P, Das H, Saha P, Biswas S . The regulation of p53 up-regulated modulator of apoptosis by JNK/c-Jun pathway in β-amyloid-induced neuron death. J Neurochem. 2015; 134(6):1091-103. DOI: 10.1111/jnc.13128. View

Strasser A, Jost P, Nagata S . The many roles of FAS receptor signaling in the immune system. Immunity. 2009; 30(2):180-92. PMC: 2956119. DOI: 10.1016/j.immuni.2009.01.001. View

Liszewski W, Naym D, Biskup E, Gniadecki R . Psoralen with ultraviolet A-induced apoptosis of cutaneous lymphoma cell lines is augmented by type I interferons via the JAK1-STAT1 pathway. Photodermatol Photoimmunol Photomed. 2017; 33(3):164-171. DOI: 10.1111/phpp.12302. View

Kunitomi C, Harada M, Takahashi N, Azhary J, Kusamoto A, Nose E . Activation of endoplasmic reticulum stress mediates oxidative stress-induced apoptosis of granulosa cells in ovaries affected by endometrioma. Mol Hum Reprod. 2019; 26(1):40-52. DOI: 10.1093/molehr/gaz066. View

10.

Li Y, Liu X, Rong F . PUMA mediates the apoptotic signal of hypoxia/reoxygenation in cardiomyocytes through mitochondrial pathway. Shock. 2011; 35(6):579-84. DOI: 10.1097/SHK.0b013e318211601a. View

11.

Green D . Paradoxical Puma Prohibits Pyruvate Pumps to Prime Pathology. Cancer Cell. 2019; 35(2):163-165. DOI: 10.1016/j.ccell.2019.01.016. View

12.

Yu J, Zhang L, Hwang P, Kinzler K, Vogelstein B . PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001; 7(3):673-82. DOI: 10.1016/s1097-2765(01)00213-1. View

13.

Stanley J, Arosh J, Burghardt R, Banu S . A fetal whole ovarian culture model for the evaluation of CrVI-induced developmental toxicity during germ cell nest breakdown. Toxicol Appl Pharmacol. 2015; 289(1):58-69. PMC: 4628871. DOI: 10.1016/j.taap.2015.09.002. View

14.

Yee K, Wilkinson S, James J, Ryan K, Vousden K . PUMA- and Bax-induced autophagy contributes to apoptosis. Cell Death Differ. 2009; 16(8):1135-45. PMC: 2711052. DOI: 10.1038/cdd.2009.28. View

15.

Liu Z, Shen M, Wu W, Li B, Weng Q, Li M . Expression of PUMA in Follicular Granulosa Cells Regulated by FoxO1 Activation During Oxidative Stress. Reprod Sci. 2014; 22(6):696-705. PMC: 4502799. DOI: 10.1177/1933719114556483. View

16.

Tuppi M, Kehrloesser S, Coutandin D, Rossi V, Luh L, Strubel A . Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63. Nat Struct Mol Biol. 2018; 25(3):261-269. DOI: 10.1038/s41594-018-0035-7. View

17.

Czabotar P, Lessene G, Strasser A, Adams J . Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Biol. 2013; 15(1):49-63. DOI: 10.1038/nrm3722. View

18.

Tichy A, Marek J, Havelek R, Pejchal J, Seifrtova M, Zarybnicka L . New Light on An Old Friend: Targeting PUMA in Radioprotection and Therapy of Cardiovascular and Neurodegenerative Diseases. Curr Drug Targets. 2018; 19(16):1943-1957. DOI: 10.2174/1389450119666180406110743. View

19.

Wyllie A, KERR J, Currie A . Cell death: the significance of apoptosis. Int Rev Cytol. 1980; 68:251-306. DOI: 10.1016/s0074-7696(08)62312-8. View

20.

Charvet C, Wissler M, Brauns-Schubert P, Wang S, Tang Y, Sigloch F . Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell. 2011; 42(5):584-96. PMC: 3184637. DOI: 10.1016/j.molcel.2011.03.033. View